17-beta-hydroxysteroid dehydrogenase type 2 (17-beta-HSD 2) (20 alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (E2DH) (Estradiol 17-beta-dehydrogenase 2) (EC 1.1.1.62) (Microsomal 17-beta-hydroxysteroid dehydrogenase) (Short chain dehydrogenase/reductase family 9C member 2) (Testosterone 17-beta-dehydrogenase) (EC 1.1.1.239)
1_MSTFF 6_ SDTAW 11_ ICLAV 16_ PTVLC 21_ GTVFC 26_ KYKKS 31_ SGQLW 36_ SWMVC 41_ LAGLC 46_ AVCLL 51_ ILSPF 56_ WGLIL 61_ FSVSC 66_ FLMYT 71_ YLSGQ 76_ ELLPV 81_ DQKAV 86_ LVTGG 91_ DCGLG 96_ HALCK 101_ YLDEL 106_ GFTVF 111_ AGVLN 116_ ENGPG 121_ AEELR 126_ RTCSP 131_ RLSVL 136_ QMDIT 141_ KPVQI 146_ KDAYS 151_ KVAAM 156_ LQDRG 161_ LWAVI 166_ NNAGV 171_ LGFPT 176_ DGELL 181_ LMTDY 186_ KQCMA 191_ VNFFG 196_ TVEVT 201_ KTFLP 206_ LLRKS 211_ KGRLV 216_ NVSSM 221_ GGGAP 226_ MERLA 231_ SYGSS 236_ KAAVT 241_ MFSSV 246_ MRLEL 251_ SKWGI 256_ KVASI 261_ QPGGF 266_ LTNIA 271_ GTSDK 276_ WEKLE 281_ KDILD 286_ HLPAE 291_ VQEDY 296_ GQDYI 301_ LAQRN 306_ FLLLI 311_ NSLAS 316_ KDFSP 321_ VLRDI 326_ QHAIL 331_ AKSPF 336_ AYYTP 341_ GKGAY 346_ LWICL 351_ AHYLP 356_ IGIYD 361_ YFAKR 366_ HFGQD 371_ KPMPR 376_ ALRMP 381_NYKKK
1: Catalyzes the NAD-dependent oxidation of the highly active 17beta-hydroxysteroids, such as estradiol (E2), testosterone (T), and dihydrotestosterone (DHT), to their less active forms and thus regulates the biological potency of these steroids. Oxidizes estradiol to estrone, testosterone to androstenedione, and dihydrotestosterone to 5alpha-androstan-3,17-dione. Also has 20-alpha-HSD activity