Amiloride-sensitive sodium channel subunit alpha (Alpha-NaCH) (Epithelial Na(+) channel subunit alpha) (Alpha-ENaC) (ENaCA) (Nonvoltage-gated sodium channel 1 subunit alpha) (SCNEA)
1_MEGNK 6_ LEEQD 11_ SSPPQ 16_ STPGL 21_ MKGNK 26_ REEQG 31_ LGPEP 36_ AAPQQ 41_ PTAEE 46_ EALIE 51_ FHRSY 56_ RELFE 61_ FFCNN 66_ TTIHG 71_ AIRLV 76_ CSQHN 81_ RMKTA 86_ FWAVL 91_ WLCTF 96_ GMMYW 101_ QFGLL 106_ FGEYF 111_ SYPVS 116_ LNINL 121_ NSDKL 126_ VFPAV 131_ TICTL 136_ NPYRY 141_ PEIKE 146_ ELEEL 151_ DRITE 156_ QTLFD 161_ LYKYS 166_ SFTTL 171_ VAGSR 176_ SRRDL 181_ RGTLP 186_ HPLQR 191_ LRVPP 196_ PPHGA 201_ RRARS 206_ VASSL 211_ RDNNP 216_ QVDWK 221_ DWKIG 226_ FQLCN 231_ QNKSD 236_ CFYQT 241_ YSSGV 246_ DAVRE 251_ WYRFH 256_ YINIL 261_ SRLPE 266_ TLPSL 271_ EEDTL 276_ GNFIF 281_ ACRFN 286_ QVSCN 291_ QANYS 296_ HFHHP 301_ MYGNC 306_ YTFND 311_ KNNSN 316_ LWMSS 321_ MPGIN 326_ NGLSL 331_ MLRAE 336_ QNDFI 341_ PLLST 346_ VTGAR 351_ VMVHG 356_ QDEPA 361_ FMDDG 366_ GFNLR 371_ PGVET 376_ SISMR 381_ KETLD 386_ RLGGD 391_ YGDCT 396_ KNGSD 401_ VPVEN 406_ LYPSK 411_ YTQQV 416_ CIHSC 421_ FQESM 426_ IKECG 431_ CAYIF 436_ YPRPQ 441_ NVEYC 446_ DYRKH 451_ SSWGY 456_ CYYKL 461_ QVDFS 466_ SDHLG 471_ CFTKC 476_ RKPCS 481_ VTSYQ 486_ LSAGY 491_ SRWPS 496_ VTSQE 501_ WVFQM 506_ LSRQN 511_ NYTVN 516_ NKRNG 521_ VAKVN 526_ IFFKE 531_ LNYKT 536_ NSESP 541_ SVTMV 546_ TLLSN 551_ LGSQW 556_ SLWFG 561_ SSVLS 566_ VVEMA 571_ ELVFD 576_ LLVIM 581_ FLMLL 586_ RRFRS 591_ RYWSP 596_ GRGGR 601_ GAQEV 606_ ASTLA 611_ SSPPS 616_ HFCPH 621_ PMSLS 626_ LSQPG 631_ PAPSP 636_ ALTAP 641_ PPAYA 646_ TLGPR 651_ PSPGG 656_ SAGAS 661_SSTCP
1: This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed:8023962, PubMed:8278374, PubMed:9792722). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:24124190, PubMed:28710092, PubMed:8278374). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (PubMed:12107247). Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance (PubMed:24124190, PubMed:28710092)
2: Not functional