Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
1_MGETL 6_ GDSPI 11_ DPESD 16_ SFTDT 21_ LSANI 26_ SQEMT 31_ MVDTE 36_ MPFWP 41_ TNFGI 46_ SSVDL 51_ SVMED 56_ HSHSF 61_ DIKPF 66_ TTVDF 71_ SSIST 76_ PHYED 81_ IPFTR 86_ TDPVV 91_ ADYKY 96_ DLKLQ 101_ EYQSA 106_ IKVEP 111_ ASPPY 116_ YSEKT 121_ QLYNK 126_ PHEEP 131_ SNSLM 136_ AIECR 141_ VCGDK 146_ ASGFH 151_ YGVHA 156_ CEGCK 161_ GFFRR 166_ TIRLK 171_ LIYDR 176_ CDLNC 181_ RIHKK 186_ SRNKC 191_ QYCRF 196_ QKCLA 201_ VGMSH 206_ NAIRF 211_ GRMPQ 216_ AEKEK 221_ LLAEI 226_ SSDID 231_ QLNPE 236_ SADLR 241_ ALAKH 246_ LYDSY 251_ IKSFP 256_ LTKAK 261_ ARAIL 266_ TGKTT 271_ DKSPF 276_ VIYDM 281_ NSLMM 286_ GEDKI 291_ KFKHI 296_ TPLQE 301_ QSKEV 306_ AIRIF 311_ QGCQF 316_ RSVEA 321_ VQEIT 326_ EYAKS 331_ IPGFV 336_ NLDLN 341_ DQVTL 346_ LKYGV 351_ HEIIY 356_ TMLAS 361_ LMNKD 366_ GVLIS 371_ EGQGF 376_ MTREF 381_ LKSLR 386_ KPFGD 391_ FMEPK 396_ FEFAV 401_ KFNAL 406_ ELDDS 411_ DLAIF 416_ IAVII 421_ LSGDR 426_ PGLLN 431_ VKPIE 436_ DIQDN 441_ LLQAL 446_ ELQLK 451_ LNHPE 456_ SSQLF 461_ AKLLQ 466_ KMTDL 471_ RQIVT 476_ EHVQL 481_ LQVIK 486_ KTETD 491_ MSLHP 496_LLQEI
1: Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated pro-inflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of BMAL1 in the blood vessels (By similarity)
2: (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein