Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
1_MDVFM 6_ KGLSK 11_ AKEGV 16_ VAAAE 21_ KTKQG 26_ VAEAA 31_ GKTKE 36_ GVLYV 41_ GSKTK 46_ EGVVH 51_ GVATV 56_ AEKTK 61_ EQVTN 66_ VGGAV 71_ VTGVT 76_ AVAQK 81_ TVEGA 86_ GSIAA 91_ ATGFV 96_ KKDQL 101_ GKNEE 106_ GAPQE 111_ GILED 116_ MPVDP 121_ DNEAY 126_ EMPSE 131_EGYQD
1: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:20798282, PubMed:26442590, PubMed:28288128, PubMed:30404828). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828). Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590)