Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
1_MDLSA 6_ LRVEE 11_ VQNVI 16_ NAMQK 21_ ILECP 26_ ICLEL 31_ IKEPV 36_ STKCD 41_ HIFCK 46_ FCMLK 51_ LLNQK 56_ KGPSQ 61_ CPLCK 66_ NDITK 71_ RSLQE 76_ STRFS 81_ QLVEE 86_ LLKII 91_ CAFQL 96_ DTGLE 101_ YANSY 106_ NFAKK 111_ ENNSP 116_ EHLKD 121_ EVSII 126_ QSMGY 131_ RNRAK 136_ RLLQS 141_ EPENP 146_ SLQET 151_ SLSVQ 156_ LSNLG 161_ TVRTL 166_ RTKQR 171_ IQPQK 176_ TSVYI 181_ ELGSD 186_ SSEDT 191_ VNKAT 196_ YCSVG 201_ DQELL 206_ QITPQ 211_ GTRDE 216_ ISLDS 221_ AKKAA 226_ CEFSE 231_ TDVTN 236_ TEHHQ 241_ PSNND 246_ LNTTE 251_ KRAAE 256_ RHPEK 261_ YQGSS 266_ VSNLH 271_ VEPCG 276_ TNTHA 281_ SSLQH 286_ ENSSL 291_ LLTKD 296_ RMNVE 301_ KAEFC 306_ NKSKQ 311_ PGLAR 316_ SQHNR 321_ WAGSK 326_ ETCND 331_ RRTPS 336_ TEKKV 341_ DLNAD 346_ PLCER 351_ KEWNK 356_ QKLPC 361_ SENPR 366_ DTEDV 371_ PWITL 376_ NSSIQ 381_ KVNEW 386_ FSRSD 391_ ELLGS 396_ DDSHD 401_ GESES 406_ NAKVA 411_ DVLDV 416_ LNEVD 421_ EYSGS 426_ SEKID 431_ LLASD 436_ PHEAL 441_ ICKSE 446_ RVHSK 451_ SVESN 456_ IEDKI 461_ FGKTY 466_ RKKAS 471_ LPNLS 476_ HVTEN 481_ LIIGA 486_ FVTEP 491_ QIIQE 496_ RPLTN 501_ KLKRK 506_ RRPTS 511_ GLHPE 516_ DFIKK 521_ ADLAV 526_ QKTPE 531_ MINQG 536_ TNQTE 541_ QNGQV 546_ MNITN 551_ SGHEN 556_ KTKGD 561_ SIQNE 566_ KNPNP 571_ IESLE 576_ KESAF 581_ KTKAE 586_ PISSS 591_ ISNME 596_ LELNI 601_ HNSKA 606_ PKKNR 611_ LRRKS 616_ STRHI 621_ HALEL 626_ VVSRN 631_ LSPPN 636_ CTELQ 641_ IDSCS 646_ SSEEI 651_ KKKKY 656_ NQMPV 661_ RHSRN 666_ LQLME 671_ GKEPA 676_ TGAKK 681_ SNKPN 686_ EQTSK 691_ RHDSD 696_ TFPEL 701_ KLTNA 706_ PGSFT 711_ KCSNT 716_ SELKE 721_ FVNPS 726_ LPREE 731_ KEEKL 736_ ETVKV 741_ SNNAE 746_ DPKDL 751_ MLSGE 756_ RVLQT 761_ ERSVE 766_ SSSIS 771_ LVPGT 776_ DYGTQ 781_ ESISL 786_ LEVST 791_ LGKAK 796_ TEPNK 801_ CVSQC 806_ AAFEN 811_ PKGLI 816_ HGCSK 821_ DNRND 826_ TEGFK 831_ YPLGH 836_ EVNHS 841_ RETSI 846_ EMEES 851_ ELDAQ 856_ YLQNT 861_ FKVSK 866_ RQSFA 871_ PFSNP 876_ GNAEE 881_ ECATF 886_ SAHSG 891_ SLKKQ 896_ SPKVT 901_ FECEQ 906_ KEENQ 911_ GKNES 916_ NIKPV 921_ QTVNI 926_ TAGFP 931_ VVGQK 936_ DKPVD 941_ NAKCS 946_ IKGGS 951_ RFCLS 956_ SQFRG 961_ NETGL 966_ ITPNK 971_ HGLLQ 976_ NPYRI 981_ PPLFP 986_ IKSFV 991_ KTKCK 996_ KNLLE 1001_ ENFEE 1006_ HSMSP 1011_ EREMG 1016_ NENIP 1021_ STVST 1026_ ISRNN 1031_ IRENV 1036_ FKEAS 1041_ SSNIN 1046_ EVGSS 1051_ TNEVG 1056_ SSINE 1061_ IGSSD 1066_ ENIQA 1071_ ELGRN 1076_ RGPKL 1081_ NAMLR 1086_ LGVLQ 1091_ PEVYK 1096_ QSLPG 1101_ SNCKH 1106_ PEIKK 1111_ QEYEE 1116_ VVQTV 1121_ NTDFS 1126_ PYLIS 1131_ DNLEQ 1136_ PMGSS 1141_ HASQV 1146_ CSETP 1151_ DDLLD 1156_ DGEIK 1161_ EDTSF 1166_ AENDI 1171_ KESSA 1176_ VFSKS 1181_ VQKGE 1186_ LSRSP 1191_ SPFTH 1196_ THLAQ 1201_ GYRRG 1206_ AKKLE 1211_ SSEEN 1216_ LSSED 1221_ EELPC 1226_ FQHLL 1231_ FGKVN 1236_ NIPSQ 1241_ STRHS 1246_ TVATE 1251_ CLSKN 1256_ TEENL 1261_ LSLKN 1266_ SLNDC 1271_ SNQVI 1276_ LAKAS 1281_ QEHHL 1286_ SEETK 1291_ CSASL 1296_ FSSQC 1301_ SELED 1306_ LTANT 1311_ NTQDP 1316_ FLIGS 1321_ SKQMR 1326_ HQSES 1331_ QGVGL 1336_ SDKEL 1341_ VSDDE 1346_ ERGTG 1351_ LEENN 1356_ QEEQS 1361_ MDSNL 1366_ GEAAS 1371_ GCESE 1376_ TSVSE 1381_ DCSGL 1386_ SSQSD 1391_ ILTTQ 1396_ QRDTM 1401_ QHNLI 1406_ KLQQE 1411_ MAELE 1416_ AVLEQ 1421_ HGSQP 1426_ SNSYP 1431_ SIISD 1436_ SSALE 1441_ DLRNP 1446_ EQSTS 1451_ EKAVL 1456_ TSQKS 1461_ SEYPI 1466_ SQNPE 1471_ GLSAD 1476_ KFEVS 1481_ ADSST 1486_ SKNKE 1491_ PGVER 1496_ SSPSK 1501_ CPSLD 1506_ DRWYM 1511_ HSCSG 1516_ SLQNR 1521_ NYPSQ 1526_ EELIK 1531_ VVDVE 1536_ EQQLE 1541_ ESGPH 1546_ DLTET 1551_ SYLPR 1556_ QDLEG 1561_ TPYLE 1566_ SGISL 1571_ FSDDP 1576_ ESDPS 1581_ EDRAP 1586_ ESARV 1591_ GNIPS 1596_ STSAL 1601_ KVPQL 1606_ KVAES 1611_ AQSPA 1616_ AAHTT 1621_ DTAGY 1626_ NAMEE 1631_ SVSRE 1636_ KPELT 1641_ ASTER 1646_ VNKRM 1651_ SMVVS 1656_ GLTPE 1661_ EFMLV 1666_ YKFAR 1671_ KHHIT 1676_ LTNLI 1681_ TEETT 1686_ HVVMK 1691_ TDAEF 1696_ VCERT 1701_ LKYFL 1706_ GIAGG 1711_ KWVVS 1716_ YFWVT 1721_ QSIKE 1726_ RKMLN 1731_ EHDFE 1736_ VRGDV 1741_ VNGRN 1746_ HQGPK 1751_ RARES 1756_ QDRKI 1761_ FRGLE 1766_ ICCYG 1771_ PFTNM 1776_ PTDQL 1781_ EWMVQ 1786_ LCGAS 1791_ VVKEL 1796_ SSFTL 1801_ GTGVH 1806_ PIVVV 1811_ QPDAW 1816_ TEDNG 1821_ FHAIG 1826_ QMCEA 1831_ PVVTR 1836_ EWVLD 1841_ SVALY 1846_ QCQEL 1851_ DTYLI 1856_PQIPH
1: E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability (PubMed:12890688, PubMed:14976165, PubMed:20351172). Regulates centrosomal microtubule nucleation (PubMed:18056443). Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle (PubMed:10724175, PubMed:11836499, PubMed:12183412, PubMed:19261748). Required for FANCD2 targeting to sites of DNA damage (PubMed:12887909). Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation (PubMed:16326698). Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks (PubMed:19369211). Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (PubMed:16818604). Acts as a transcriptional activator (PubMed:20160719)