Guanine nucleotide-binding protein G(olf) subunit alpha (Adenylate cyclase-stimulating G alpha protein, olfactory type)
1_MGCLG 6_ GNSKT 11_ TEDQG 16_ VDEKE 21_ RREAN 26_ KKIEK 31_ QLQKE 36_ RLAYK 41_ ATHRL 46_ LLLGA 51_ GESGK 56_ STIVK 61_ QMRIL 66_ HVNGF 71_ NPEEK 76_ KQKIL 81_ DIRKN 86_ VKDAI 91_ VTIVS 96_ AMSTI 101_ IPPVP 106_ LANPE 111_ NQFRS 116_ DYIKS 121_ IAPIT 126_ DFEYS 131_ QEFFD 136_ HVKKL 141_ WDDEG 146_ VKACF 151_ ERSNE 156_ YQLID 161_ CAQYF 166_ LERID 171_ SVSLV 176_ DYTPT 181_ DQDLL 186_ RCRVL 191_ TSGIF 196_ ETRFQ 201_ VDKVN 206_ FHMFD 211_ VGGQR 216_ DERRK 221_ WIQCF 226_ NDVTA 231_ IIYVA 236_ ACSSY 241_ NMVIR 246_ EDNNT 251_ NRLRE 256_ SLDLF 261_ ESIWN 266_ NRWLR 271_ TISII 276_ LFLNK 281_ QDMLA 286_ EKVLA 291_ GKSKI 296_ EDYFP 301_ EYANY 306_ TVPED 311_ ATPDA 316_ GEDPK 321_ VTRAK 326_ FFIRD 331_ LFLRI 336_ STATG 341_ DGKHY 346_ CYPHF 351_ TCAVD 356_ TENIR 361_ RVFND 366_ CRDII 371_ QRMHL 376_KQYEL
1: Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs) (By similarity). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation (By similarity). Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP (By similarity)