Vitamin K-dependent gamma-carboxylase (EC 4.1.1.90) (Gamma-glutamyl carboxylase) (Peptidyl-glutamate 4-carboxylase) (Vitamin K gamma glutamyl carboxylase)
1_MAVSA 6_ GSART 11_ SPSSD 16_ KVQKD 21_ KAELI 26_ SGPRQ 31_ DSRIG 36_ KLLGF 41_ EWTDL 46_ SSWRR 51_ LVTLL 56_ NRPTD 61_ PASLA 66_ VFRFL 71_ FGFLM 76_ VLDIP 81_ QERGL 86_ SSLDR 91_ KYLDG 96_ LDVCR 101_ FPLLD 106_ ALRPL 111_ PLDWM 116_ YLVYT 121_ IMFLG 126_ ALGMM 131_ LGLCY 136_ RISCV 141_ LFLLP 146_ YWYVF 151_ LLDKT 156_ SWNNH 161_ SYLYG 166_ LLAFQ 171_ LTFMD 176_ ANHYW 181_ SVDGL 186_ LNAHR 191_ RNAHV 196_ PLWNY 201_ AVLRG 206_ QIFIV 211_ YFIAG 216_ VKKLD 221_ ADWVE 226_ GYSME 231_ YLSRH 236_ WLFSP 241_ FKLLL 246_ SEELT 251_ SLLVV 256_ HWGGL 261_ LLDLS 266_ AGFLL 271_ FFDVS 276_ RSIGL 281_ FFVSY 286_ FHCMN 291_ SQLFS 296_ IGMFS 301_ YVMLA 306_ SSPLF 311_ CSPEW 316_ PRKLV 321_ SYCPR 326_ RLQQL 331_ LPLKA 336_ APQPS 341_ VSCVY 346_ KRSRG 351_ KSGQK 356_ PGLRH 361_ QLGAA 366_ FTLLY 371_ LLEQL 376_ FLPYS 381_ HFLTQ 386_ GYNNW 391_ TNGLY 396_ GYSWD 401_ MMVHS 406_ RSHQH 411_ VKITY 416_ RDGRT 421_ GELGY 426_ LNPGV 431_ FTQSR 436_ RWKDH 441_ ADMLK 446_ QYATC 451_ LSRLL 456_ PKYNV 461_ TEPQI 466_ YFDIW 471_ VSIND 476_ RFQQR 481_ IFDPR 486_ VDIVQ 491_ AAWSP 496_ FQRTS 501_ WVQPL 506_ LMDLS 511_ PWRAK 516_ LQEIK 521_ SSLDN 526_ HTEVV 531_ FIADF 536_ PGLHL 541_ ENFVS 546_ EDLGN 551_ TSIQL 556_ LQGEV 561_ TVELV 566_ AEQKN 571_ QTLRE 576_ GEKMQ 581_ LPAGE 586_ YHKVY 591_ TTSPS 596_ PSCYM 601_ YVYVN 606_ TTELA 611_ LEQDL 616_ AYLQE 621_ LKEKV 626_ ENGSE 631_ TGPLP 636_ PELQP 641_ LLEGE 646_ VKGGP 651_ EPTPL 656_ VQTFL 661_ RRQQR 666_ LQEIE 671_ RRRNT 676_ PFHER 681_ FFRFL 686_ LRKLY 691_ VFRRS 696_ FLMTC 701_ ISLRN 706_ LILGR 711_ PSLEQ 716_ LAQEV 721_ TYANL 726_ RPFEA 731_ VGELN 736_ PSNTD 741_ SSHSN 746_ PPESN 751_PDPVH
1: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide (PubMed:17073445). Catalyzes gamma-carboxylation of various proteins, such as blood coagulation factors (F2, F7, F9 and F10), osteocalcin (BGLAP) or matrix Gla protein (MGP) (PubMed:17073445)