Hyaluronidase PH-20 (Hyal-PH20) (EC 3.2.1.35) (Hyaluronoglucosaminidase PH-20) (Sperm adhesion molecule 1) (Sperm surface protein PH-20)
1_MGVLK 6_ FKHIF 11_ FRSFV 16_ KSSGV 21_ SQIVF 26_ TFLLI 31_ PCCLT 36_ LNFRA 41_ PPVIP 46_ NVPFL 51_ WAWNA 56_ PSEFC 61_ LGKFD 66_ EPLDM 71_ SLFSF 76_ IGSPR 81_ INATG 86_ QGVTI 91_ FYVDR 96_ LGYYP 101_ YIDSI 106_ TGVTV 111_ NGGIP 116_ QKISL 121_ QDHLD 126_ KAKKD 131_ ITFYM 136_ PVDNL 141_ GMAVI 146_ DWEEW 151_ RPTWA 156_ RNWKP 161_ KDVYK 166_ NRSIE 171_ LVQQQ 176_ NVQLS 181_ LTEAT 186_ EKAKQ 191_ EFEKA 196_ GKDFL 201_ VETIK 206_ LGKLL 211_ RPNHL 216_ WGYYL 221_ FPDCY 226_ NHHYK 231_ KPGYN 236_ GSCFN 241_ VEIKR 246_ NDDLS 251_ WLWNE 256_ STALY 261_ PSIYL 266_ NTQQS 271_ PVAAT 276_ LYVRN 281_ RVREA 286_ IRVSK 291_ IPDAK 296_ SPLPV 301_ FAYTR 306_ IVFTD 311_ QVLKF 316_ LSQDE 321_ LVYTF 326_ GETVA 331_ LGASG 336_ IVIWG 341_ TLSIM 346_ RSMKS 351_ CLLLD 356_ NYMET 361_ ILNPY 366_ IINVT 371_ LAAKM 376_ CSQVL 381_ CQEQG 386_ VCIRK 391_ NWNSS 396_ DYLHL 401_ NPDNF 406_ AIQLE 411_ KGGKF 416_ TVRGK 421_ PTLED 426_ LEQFS 431_ EKFYC 436_ SCYST 441_ LSCKE 446_ KADVK 451_ DTDAV 456_ DVCIA 461_ DGVCI 466_ DAFLK 471_ PPMET 476_ EEPQI 481_ FYNAS 486_ PSTLS 491_ ATMFI 496_ VSILF 501_LIISS
1: Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid