Lysosomal acid lipase/cholesteryl ester hydrolase (Acid cholesteryl ester hydrolase) (LAL) (EC 3.1.1.13) (Cholesteryl esterase) (Lipase A) (Sterol esterase)
1_MKMRF 6_ LGLVV 11_ CLVLW 16_ TLHSE 21_ GSGGK 26_ LTAVD 31_ PETNM 36_ NVSEI 41_ ISYWG 46_ FPSEE 51_ YLVET 56_ EDGYI 61_ LCLNR 66_ IPHGR 71_ KNHSD 76_ KGPKP 81_ VVFLQ 86_ HGLLA 91_ DSSNW 96_ VTNLA 101_ NSSLG 106_ FILAD 111_ AGFDV 116_ WMGNS 121_ RGNTW 126_ SRKHK 131_ TLSVS 136_ QDEFW 141_ AFSYD 146_ EMAKY 151_ DLPAS 156_ INFIL 161_ NKTGQ 166_ EQVYY 171_ VGHSQ 176_ GTTIG 181_ FIAFS 186_ QIPEL 191_ AKRIK 196_ MFFAL 201_ GPVAS 206_ VAFCT 211_ SPMAK 216_ LGRLP 221_ DHLIK 226_ DLFGD 231_ KEFLP 236_ QSAFL 241_ KWLGT 246_ HVCTH 251_ VILKE 256_ LCGNL 261_ CFLLC 266_ GFNER 271_ NLNMS 276_ RVDVY 281_ TTHSP 286_ AGTSV 291_ QNMLH 296_ WSQAV 301_ KFQKF 306_ QAFDW 311_ GSSAK 316_ NYFHY 321_ NQSYP 326_ PTYNV 331_ KDMLV 336_ PTAVW 341_ SGGHD 346_ WLADV 351_ YDVNI 356_ LLTQI 361_ TNLVF 366_ HESIP 371_ EWEHL 376_ DFIWG 381_ LDAPW 386_ RLYNK 391_IINLM
1: Catalyzes the deacylation of cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol (PubMed:15269241, PubMed:1718995, PubMed:7204383, PubMed:8112342, PubMed:9633819). Hydrolyzes triglycerides (1,2,3-triacylglycerol) and diglycerides (such as 1,2-diacylglycerol and 1,3-diacylglycerol) with preference for the acyl moieties at the sn-1 or sn-3 positions (PubMed:7204383, PubMed:8112342)