V-type proton ATPase catalytic subunit A (V-ATPase subunit A) (EC 7.1.2.2) (V-ATPase 69 kDa subunit) (Vacuolar ATPase isoform VA68) (Vacuolar proton pump subunit alpha)
1_MDFSK 6_ LPKIL 11_ DEDKE 16_ STFGY 21_ VHGVS 26_ GPVVT 31_ ACDMA 36_ GAAMY 41_ ELVRV 46_ GHSEL 51_ VGEII 56_ RLEGD 61_ MATIQ 66_ VYEET 71_ SGVSV 76_ GDPVL 81_ RTGKP 86_ LSVEL 91_ GPGIM 96_ GAIFD 101_ GIQRP 106_ LSDIS 111_ SQTQS 116_ IYIPR 121_ GVNVS 126_ ALSRD 131_ IKWDF 136_ TPCKN 141_ LRVGS 146_ HITGG 151_ DIYGI 156_ VSENS 161_ LIKHK 166_ IMLPP 171_ RNRGT 176_ VTYIA 181_ PPGNY 186_ DTSDV 191_ VLELE 196_ FEGVK 201_ EKFTM 206_ VQVWP 211_ VRQVR 216_ PVTEK 221_ LPANH 226_ PLLTG 231_ QRVLD 236_ ALFPC 241_ VQGGT 246_ TAIPG 251_ AFGCG 256_ KTVIS 261_ QSLSK 266_ YSNSD 271_ VIIYV 276_ GCGER 281_ GNEMS 286_ EVLRD 291_ FPELT 296_ MEVDG 301_ KVESI 306_ MKRTA 311_ LVANT 316_ SNMPV 321_ AAREA 326_ SIYTG 331_ ITLSE 336_ YFRDM 341_ GYHVS 346_ MMADS 351_ TSRWA 356_ EALRE 361_ ISGRL 366_ AEMPA 371_ DSGYP 376_ AYLGA 381_ RLASF 386_ YERAG 391_ RVKCL 396_ GNPER 401_ EGSVS 406_ IVGAV 411_ SPPGG 416_ DFSDP 421_ VTSAT 426_ LGIVQ 431_ VFWGL 436_ DKKLA 441_ QRKHF 446_ PSVNW 451_ LISYS 456_ KYMRA 461_ LDEYY 466_ DKHFT 471_ EFVPL 476_ RTKAK 481_ EILQE 486_ EEDLA 491_ EIVQL 496_ VGKAS 501_ LAETD 506_ KITLE 511_ VAKLI 516_ KDDFL 521_ QQNGY 526_ TPYDR 531_ FCPFY 536_ KTVGM 541_ LSNMI 546_ AFYDM 551_ ARRAV 556_ ETTAQ 561_ SDNKI 566_ TWSII 571_ REHMG 576_ DILYK 581_ LSSMK 586_ FKDPL 591_ KDGEA 596_ KIKSD 601_ YAQLL 606_ EDMQN 611_AFRSL
1: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:8463241). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:32001091). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in neurite development and synaptic connectivity (PubMed:29668857)
2: (Microbial infection) Plays an important role in virion uncoating during Rabies virus replication after membrane fusion. Specifically, participates in the dissociation of incoming viral matrix M proteins uncoating through direct interaction