Eukaryotic initiation factor 4A-III (eIF-4A-III) (eIF4A-III) (EC 3.6.4.13) (ATP-dependent RNA helicase DDX48) (ATP-dependent RNA helicase eIF4A-3) (DEAD box protein 48) (Eukaryotic initiation factor 4A-like NUK-34) (Eukaryotic translation initiation factor 4A isoform 3) (Nuclear matrix protein 265) (NMP 265) (hNMP 265) [Cleaved into: Eukaryotic initiation factor 4A-III, N-terminally processed]
1_MATTA 6_ TMATS 11_ GSARK 16_ RLLKE 21_ EDMTK 26_ VEFET 31_ SEEVD 36_ VTPTF 41_ DTMGL 46_ REDLL 51_ RGIYA 56_ YGFEK 61_ PSAIQ 66_ QRAIK 71_ QIIKG 76_ RDVIA 81_ QSQSG 86_ TGKTA 91_ TFSIS 96_ VLQCL 101_ DIQVR 106_ ETQAL 111_ ILAPT 116_ RELAV 121_ QIQKG 126_ LLALG 131_ DYMNV 136_ QCHAC 141_ IGGTN 146_ VGEDI 151_ RKLDY 156_ GQHVV 161_ AGTPG 166_ RVFDM 171_ IRRRS 176_ LRTRA 181_ IKMLV 186_ LDEAD 191_ EMLNK 196_ GFKEQ 201_ IYDVY 206_ RYLPP 211_ ATQVV 216_ LISAT 221_ LPHEI 226_ LEMTN 231_ KFMTD 236_ PIRIL 241_ VKRDE 246_ LTLEG 251_ IKQFF 256_ VAVER 261_ EEWKF 266_ DTLCD 271_ LYDTL 276_ TITQA 281_ VIFCN 286_ TKRKV 291_ DWLTE 296_ KMREA 301_ NFTVS 306_ SMHGD 311_ MPQKE 316_ RESIM 321_ KEFRS 326_ GASRV 331_ LISTD 336_ VWARG 341_ LDVPQ 346_ VSLII 351_ NYDLP 356_ NNREL 361_ YIHRI 366_ GRSGR 371_ YGRKG 376_ VAINF 381_ VKNDD 386_ IRILR 391_ DIEQY 396_ YSTQI 401_ DEMPM 406_NVADL
1: ATP-dependent RNA helicase (PubMed:16170325). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:22961380, PubMed:28076346, PubMed:28502770, PubMed:29301961). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs (PubMed:16170325, PubMed:16209946, PubMed:16314458, PubMed:16923391, PubMed:16931718, PubMed:19033377, PubMed:20479275). The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the function is different from the established EJC assembly (PubMed:22203037). Involved in craniofacial development (PubMed:24360810)