Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1 (NC1)]
1_MAPYP 6_ CGCHI 11_ LLLLF 16_ CCLAA 21_ ARANL 26_ LNLNW 31_ LWFNN 36_ EDTSH 41_ AATTI 46_ PEPQG 51_ PLPVQ 56_ PTADT 61_ TTHVT 66_ PRNGS 71_ TEPAT 76_ APGSP 81_ EPPSE 86_ LLEDG 91_ QDTPT 96_ SAESP 101_ DAPEE 106_ NIAGV 111_ GAEIL 116_ NVAKG 121_ IRSFV 126_ QLWND 131_ TVPTE 136_ SLARA 141_ ETLVL 146_ ETPVG 151_ PLALA 156_ GPSST 161_ PQENG 166_ TTLWP 171_ SRGIP 176_ SSPGA 181_ HTTEA 186_ GTLPA 191_ PTPSP 196_ PSLGR 201_ PWAPL 206_ TGPSV 211_ PPPSS 216_ GRASL 221_ SSLLG 226_ GAPPW 231_ GSLQD 236_ PDSQG 241_ LSPAA 246_ AAPSQ 251_ QLQRP 256_ DVRLR 261_ TPLLH 266_ PLVMG 271_ SLGKH 276_ AAPSA 281_ FSSGL 286_ PGALS 291_ QVAVT 296_ TLTRD 301_ SGAWV 306_ SHVAN 311_ SVGPG 316_ LANNS 321_ ALLGA 326_ DPEAP 331_ AGRCL 336_ PLPPS 341_ LPVCG 346_ HLGIS 351_ RFWLP 356_ NHLHH 361_ ESGEQ 366_ VRAGA 371_ RAWGG 376_ LLQTH 381_ CHPFL 386_ AWFFC 391_ LLLVP 396_ PCGSV 401_ PPPAP 406_ PPCCQ 411_ FCEAL 416_ QDACW 421_ SRLGG 426_ GRLPV 431_ ACASL 436_ PTQED 441_ GYCVL 446_ IGPAA 451_ ERISE 456_ EVGLL 461_ QLLGD 466_ PPPQQ 471_ VTQTD 476_ DPDVG 481_ LAYVF 486_ GPDAN 491_ SGQVA 496_ RYHFP 501_ SLFFR 506_ DFSLL 511_ FHIRP 516_ ATEGP 521_ GVLFA 526_ ITDSA 531_ QAMVL 536_ LGVKL 541_ SGVQD 546_ GHQDI 551_ SLLYT 556_ EPGAG 561_ QTHTA 566_ ASFRL 571_ PAFVG 576_ QWTHL 581_ ALSVA 586_ GGFVA 591_ LYVDC 596_ EEFQR 601_ MPLAR 606_ SSRGL 611_ ELEPG 616_ AGLFV 621_ AQAGG 626_ ADPDK 631_ FQGVI 636_ AELKV 641_ RRDPQ 646_ VSPMH 651_ CLDEE 656_ GDDSD 661_ GASGD 666_ SGSGL 671_ GDARE 676_ LLREE 681_ TGAAL 686_ KPRLP 691_ APPPV 696_ TTPPL 701_ AGGSS 706_ TEDSR 711_ SEEVE 716_ EQTTV 721_ ASLGA 726_ QTLPG 731_ SDSVS 736_ TWDGS 741_ VRTPG 746_ GRVKE 751_ GGLKG 756_ QKGEP 761_ GVPGP 766_ PGRAG 771_ PPGSP 776_ CLPGP 781_ PGLPC 786_ PVSPL 791_ GPAGP 796_ ALQTV 801_ PGPQG 806_ PPGPP 811_ GRDGT 816_ PGRDG 821_ EPGDP 826_ GEDGK 831_ PGDTG 836_ PQGFP 841_ GTPGD 846_ VGPKG 851_ DKGDP 856_ GVGER 861_ GPPGP 866_ QGPPG 871_ PPGPS 876_ FRHDK 881_ LTFID 886_ MEGSG 891_ FGGDL 896_ EALRG 901_ PRGFP 906_ GPPGP 911_ PGVPG 916_ LPGEP 921_ GRFGV 926_ NSSDV 931_ PGPAG 936_ LPGVP 941_ GREGP 946_ PGFPG 951_ LPGPP 956_ GPPGR 961_ EGPPG 966_ RTGQK 971_ GSLGE 976_ AGAPG 981_ HKGSK 986_ GAPGP 991_ AGARG 996_ ESGLA 1001_ GAPGP 1006_ AGPPG 1011_ PPGPP 1016_ GPPGP 1021_ GLPAG 1026_ FDDME 1031_ GSGGP 1036_ FWSTA 1041_ RSADG 1046_ PQGPP 1051_ GLPGL 1056_ KGDPG 1061_ VPGLP 1066_ GAKGE 1071_ VGADG 1076_ VPGFP 1081_ GLPGR 1086_ EGIAG 1091_ PQGPK 1096_ GDRGS 1101_ RGEKG 1106_ DPGKD 1111_ GVGQP 1116_ GLPGP 1121_ PGPPG 1126_ PVVYV 1131_ SEQDG 1136_ SVLSV 1141_ PGPEG 1146_ RPGFA 1151_ GFPGP 1156_ AGPKG 1161_ NLGSK 1166_ GERGS 1171_ PGPKG 1176_ EKGEP 1181_ GSIFS 1186_ PDGGA 1191_ LGPAQ 1196_ KGAKG 1201_ EPGFR 1206_ GPPGP 1211_ YGRPG 1216_ YKGEI 1221_ GFPGR 1226_ PGRPG 1231_ MNGLK 1236_ GEKGE 1241_ PGDAS 1246_ LGFGM 1251_ RGMPG 1256_ PPGPP 1261_ GPPGP 1266_ PGTPV 1271_ YDSNV 1276_ FAESS 1281_ RPGPP 1286_ GLPGN 1291_ QGPPG 1296_ PKGAK 1301_ GEVGP 1306_ PGPPG 1311_ QFPFD 1316_ FLQLE 1321_ AEMKG 1326_ EKGDR 1331_ GDAGQ 1336_ KGERG 1341_ EPGGG 1346_ GFFGS 1351_ SLPGP 1356_ PGPPG 1361_ PPGPR 1366_ GYPGI 1371_ PGPKG 1376_ ESIRG 1381_ QPGPP 1386_ GPQGP 1391_ PGIGY 1396_ EGRQG 1401_ PPGPP 1406_ GPPGP 1411_ PSFPG 1416_ PHRQT 1421_ ISVPG 1426_ PPGPP 1431_ GPPGP 1436_ PGTMG 1441_ ASSGV 1446_ RLWAT 1451_ RQAML 1456_ GQVHE 1461_ VPEGW 1466_ LIFVA 1471_ EQEEL 1476_ YVRVQ 1481_ NGFRK 1486_ VQLEA 1491_ RTPLP 1496_ RGTDN 1501_ EVAAL 1506_ QPPVV 1511_ QLHDS 1516_ NPYPR 1521_ REHPH 1526_ PTARP 1531_ WRADD 1536_ ILASP 1541_ PRLPE 1546_ PQPYP 1551_ GAPHH 1556_ SSYVH 1561_ LRPAR 1566_ PTSPP 1571_ AHSHR 1576_ DFQPV 1581_ LHLVA 1586_ LNSPL 1591_ SGGMR 1596_ GIRGA 1601_ DFQCF 1606_ QQARA 1611_ VGLAG 1616_ TFRAF 1621_ LSSRL 1626_ QDLYS 1631_ IVRRA 1636_ DRAAV 1641_ PIVNL 1646_ KDELL 1651_ FPSWE 1656_ ALFSG 1661_ SEGPL 1666_ KPGAR 1671_ IFSFD 1676_ GKDVL 1681_ RHPTW 1686_ PQKSV 1691_ WHGSD 1696_ PNGRR 1701_ LTESY 1706_ CETWR 1711_ TEAPS 1716_ ATGQA 1721_ SSLLG 1726_ GRLLG 1731_ QSAAS 1736_ CHHAY 1741_ IVLCI 1746_ENSFM
1: Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube
2: May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling
3: Potently inhibits endothelial cell proliferation and angiogenesis (PubMed:9459295). May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity). May negatively regulate the activity of homotrimeric non-collagenous domain 1 (PubMed:11257123)