Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit (DDOST 48 kDa subunit) (Oligosaccharyl transferase 48 kDa subunit)
1_MGYFR 6_ CARAG 11_ SFGRR 16_ RKMEP 21_ STAAR 26_ AWALF 31_ WLLLP 36_ LLGAV 41_ CASGP 46_ RTLVL 51_ LDNLN 56_ VRETH 61_ SLFFR 66_ SLKDR 71_ GFELT 76_ FKTAD 81_ DPSLS 86_ LIKYG 91_ EFLYD 96_ NLIIF 101_ SPSVE 106_ DFGGN 111_ INVET 116_ ISAFI 121_ DGGGS 126_ VLVAA 131_ SSDIG 136_ DPLRE 141_ LGSEC 146_ GIEFD 151_ EEKTA 156_ VIDHH 161_ NYDIS 166_ DLGQH 171_ TLIVA 176_ DTENL 181_ LKAPT 186_ IVGKS 191_ SLNPI 196_ LFRGV 201_ GMVAD 206_ PDNPL 211_ VLDIL 216_ TGSST 221_ SYSFF 226_ PDKPI 231_ TQYPH 236_ AVGKN 241_ TLLIA 246_ GLQAR 251_ NNARV 256_ IFSGS 261_ LDFFS 266_ DSFFN 271_ SAVQK 276_ AAPGS 281_ QRYSQ 286_ TGNYE 291_ LAVAL 296_ SRWVF 301_ KEEGV 306_ LRVGP 311_ VSHHR 316_ VGETA 321_ PPNAY 326_ TVTDL 331_ VEYSI 336_ VIQQL 341_ SNGKW 346_ VPFDG 351_ DDIQL 356_ EFVRI 361_ DPFVR 366_ TFLKK 371_ KGGKY 376_ SVQFK 381_ LPDVY 386_ GVFQF 391_ KVDYN 396_ RLGYT 401_ HLYSS 406_ TQVSV 411_ RPLQH 416_ TQYER 421_ FIPSA 426_ YPYYA 431_ SAFSM 436_ MLGLF 441_ IFSIV 446_ FLHMK 451_EKEKS
1: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (PubMed:22467853)