Acidic leucine-rich nuclear phosphoprotein 32 family member A (Acidic nuclear phosphoprotein pp32) (pp32) (Leucine-rich acidic nuclear protein) (LANP) (Mapmodulin) (Potent heat-stable protein phosphatase 2A inhibitor I1PP2A) (Putative HLA-DR-associated protein I) (PHAPI)
1_MEMGR 6_ RIHLE 11_ LRNRT 16_ PSDVK 21_ ELVLD 26_ NSRSN 31_ EGKLE 36_ GLTDE 41_ FEELE 46_ FLSTI 51_ NVGLT 56_ SIANL 61_ PKLNK 66_ LKKLE 71_ LSDNR 76_ VSGGL 81_ EVLAE 86_ KCPNL 91_ THLNL 96_ SGNKI 101_ KDLST 106_ IEPLK 111_ KLENL 116_ KSLDL 121_ FNCEV 126_ TNLND 131_ YRENV 136_ FKLLP 141_ QLTYL 146_ DGYDR 151_ DDKEA 156_ PDSDA 161_ EGYVE 166_ GLDDE 171_ EEDED 176_ EEEYD 181_ EDAQV 186_ VEDEE 191_ DEDEE 196_ EEGEE 201_ EDVSG 206_ EEEED 211_ EEGYN 216_ DGEVD 221_ DEEDE 226_ EELGE 231_ EERGQ 236_ KRKRE 241_PEDEG
1: Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription (PubMed:10400610, PubMed:11360199, PubMed:16341127, PubMed:18439902). Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation (PubMed:18439902). In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltranferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking (PubMed:11830591). Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:16341127). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R) (PubMed:18180367). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (PubMed:15642345, PubMed:17557114)
2: (Microbial infection) Plays an essential role in influenza A, B and C viral genome replication (PubMed:30666459, PubMed:32694517, PubMed:33045004, PubMed:33208942). Mechanistically, mediates the assembly of the viral replicase asymmetric dimers composed of PB1, PB2 and PA via its N-terminal region (PubMed:33208942). Also plays an essential role in foamy virus mRNA export from the nucleus (PubMed:21159877)