Homeobox protein cut-like 1 (CCAAT displacement protein) (CDP) (CDP/Cux p200) (Homeobox protein cux-1) [Cleaved into: CDP/Cux p110]
1_MLCVA 6_ GARLK 11_ RELDA 16_ TATVL 21_ ANRQD 26_ ESEQS 31_ RKRLI 36_ EQSRE 41_ FKKNT 46_ PEDLR 51_ KQVAP 56_ LLKSF 61_ QGEID 66_ ALSKR 71_ SKEAE 76_ AAFLN 81_ VYKRL 86_ IDVPD 91_ PVPAL 96_ DLGQQ 101_ LQLKV 106_ QRLHD 111_ IETEN 116_ QKLRE 121_ TLEEY 126_ NKEFA 131_ EVKNQ 136_ EVTIK 141_ ALKEK 146_ IREYE 151_ QTLKN 156_ QAETI 161_ ALEKE 166_ QKLQN 171_ DFAEK 176_ ERKLQ 181_ ETQMS 186_ TTSKL 191_ EEAEH 196_ KVQSL 201_ QTALE 206_ KTRTE 211_ LFDLK 216_ TKYDE 221_ ETTAK 226_ ADEIE 231_ MIMTD 236_ LERAN 241_ QRAEV 246_ AQREA 251_ ETLRE 256_ QLSSA 261_ NHSLQ 266_ LASQI 271_ QKAPD 276_ VEQAI 281_ EVLTR 286_ SSLEV 291_ ELAAK 296_ EREIA 301_ QLVED 306_ VQRLQ 311_ ASLTK 316_ LRENS 321_ ASQIS 326_ QLEQQ 331_ LSAKN 336_ STLKQ 341_ LEEKL 346_ KGQAD 351_ YEEVK 356_ KELNI 361_ LKSME 366_ FAPSE 371_ GAGTQ 376_ DAAKP 381_ LEVLL 386_ LEKNR 391_ SLQSE 396_ NAALR 401_ ISNSD 406_ LSGSA 411_ RRKGK 416_ DQPES 421_ RRPGS 426_ LPAPP 431_ PSQLP 436_ RNPGE 441_ QASNT 446_ NGTHQ 451_ FSPAG 456_ LSQDF 461_ FSSSL 466_ ASPSL 471_ PLAST 476_ GKFAL 481_ NSLLQ 486_ RQLMQ 491_ SFYSK 496_ AMQEA 501_ GSTSM 506_ IFSTG 511_ PYSTN 516_ SISSQ 521_ SPLQQ 526_ SPDVN 531_ GMAPS 536_ PSQSE 541_ SAGSV 546_ SEGEE 551_ MDTAE 556_ IARQV 561_ KEQLI 566_ KHNIG 571_ QRIFG 576_ HYVLG 581_ LSQGS 586_ VSEIL 591_ ARPKP 596_ WNKLT 601_ VRGKE 606_ PFHKM 611_ KQFLS 616_ DEQNI 621_ LALRS 626_ IQGRQ 631_ RENPG 636_ QSLNR 641_ LFQEV 646_ PKRRN 651_ GSEGN 656_ ITTRI 661_ RASET 666_ GSDEA 671_ IKSIL 676_ EQAKR 681_ ELQVQ 686_ KTAEP 691_ AQPSS 696_ ASGSG 701_ NSDDA 706_ IRSIL 711_ QQARR 716_ EMEAQ 721_ QAALD 726_ PALKQ 731_ APLSQ 736_ SDITI 741_ LTPKL 746_ LSTSP 751_ MPTVS 756_ SYPPL 761_ AISLK 766_ KPSAA 771_ PEAGA 776_ SALPN 781_ PPALK 786_ KEAQD 791_ APGLD 796_ PQGAA 801_ DCAQG 806_ VLRQV 811_ KNEVG 816_ RSGAW 821_ KDHWW 826_ SAVQP 831_ ERRNA 836_ ASSEE 841_ AKAEE 846_ TGGGK 851_ EKGSG 856_ GSGGG 861_ SQPRA 866_ ERSQL 871_ QGPSS 876_ SEYWK 881_ EWPSA 886_ ESPYS 891_ QSSEL 896_ SLTGA 901_ SRSET 906_ PQNSP 911_ LPSSP 916_ IVPMS 921_ KPTKP 926_ SVPPL 931_ TPEQY 936_ EVYMY 941_ QEVDT 946_ IELTR 951_ QVKEK 956_ LAKNG 961_ ICQRI 966_ FGEKV 971_ LGLSQ 976_ GSVSD 981_ MLSRP 986_ KPWSK 991_ LTQKG 996_ REPFI 1001_ RMQLW 1006_ LNGEL 1011_ GQGVL 1016_ PVQGQ 1021_ QQGPV 1026_ LHSVT 1031_ SLQDP 1036_ LQQGC 1041_ VSSES 1046_ TPKTS 1051_ ASCSP 1056_ APESP 1061_ MSSSE 1066_ SVKSL 1071_ TELVQ 1076_ QPCPP 1081_ IEASK 1086_ DSKPP 1091_ EPSDP 1096_ PASDS 1101_ QPTTP 1106_ LPLSG 1111_ HSALS 1116_ IQELV 1121_ AMSPE 1126_ LDTYG 1131_ ITKRV 1136_ KEVLT 1141_ DNNLG 1146_ QRLFG 1151_ ETILG 1156_ LTQGS 1161_ VSDLL 1166_ ARPKP 1171_ WHKLS 1176_ LKGRE 1181_ PFVRM 1186_ QLWLN 1191_ DPNNV 1196_ EKLMD 1201_ MKRME 1206_ KKAYM 1211_ KRRHS 1216_ SVSDS 1221_ QPCEP 1226_ PSVGT 1231_ EYSQG 1236_ ASPQP 1241_ QHQLK 1246_ KPRVV 1251_ LAPEE 1256_ KEALK 1261_ RAYQQ 1266_ KPYPS 1271_ PKTIE 1276_ DLATQ 1281_ LNLKT 1286_ STVIN 1291_ WFHNY 1296_ RSRIR 1301_ RELFI 1306_ EEIQA 1311_ GSQGQ 1316_ AGASD 1321_ SPSAR 1326_ SGRAA 1331_ PSSEG 1336_ DSCDG 1341_ VEATE 1346_ GPGSA 1351_ DTEEP 1356_ KSQGE 1361_ AEREE 1366_ VPRPA 1371_ EQTEP 1376_ PPSGT 1381_ PGPDD 1386_ ARDDD 1391_ HEGGP 1396_ VEGPG 1401_ PLPSP 1406_ ASATA 1411_ TAAPA 1416_ APEDA 1421_ ATSAA 1426_ AAPGE 1431_ GPAAP 1436_ SSAPP 1441_ PSNSS 1446_ SSSAP 1451_ RRPSS 1456_ LQSLF 1461_ GLPEA 1466_ AGARD 1471_ SRDNP 1476_ LRKKK 1481_ AANLN 1486_ SIIHR 1491_ LEKAA 1496_SREEP
1: Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator
2: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1