Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12)
1_MKFLL 6_ ILLLQ 11_ ATASG 16_ ALPLN 21_ SSTSL 26_ EKNNV 31_ LFGER 36_ YLEKF 41_ YGLEI 46_ NKLPV 51_ TKMKY 56_ SGNLM 61_ KEKIQ 66_ EMQHF 71_ LGLKV 76_ TGQLD 81_ TSTLE 86_ MMHAP 91_ RCGVP 96_ DVHHF 101_ REMPG 106_ GPVWR 111_ KHYIT 116_ YRINN 121_ YTPDM 126_ NREDV 131_ DYAIR 136_ KAFQV 141_ WSNVT 146_ PLKFS 151_ KINTG 156_ MADIL 161_ VVFAR 166_ GAHGD 171_ FHAFD 176_ GKGGI 181_ LAHAF 186_ GPGSG 191_ IGGDA 196_ HFDED 201_ EFWTT 206_ HSGGT 211_ NLFLT 216_ AVHEI 221_ GHSLG 226_ LGHSS 231_ DPKAV 236_ MFPTY 241_ KYVDI 246_ NTFRL 251_ SADDI 256_ RGIQS 261_ LYGDP 266_ KENQR 271_ LPNPD 276_ NSEPA 281_ LCDPN 286_ LSFDA 291_ VTTVG 296_ NKIFF 301_ FKDRF 306_ FWLKV 311_ SERPK 316_ TSVNL 321_ ISSLW 326_ PTLPS 331_ GIEAA 336_ YEIEA 341_ RNQVF 346_ LFKDD 351_ KYWLI 356_ SNLRP 361_ EPNYP 366_ KSIHS 371_ FGFPN 376_ FVKKI 381_ DAAVF 386_ NPRFY 391_ RTYFF 396_ VDNQY 401_ WRYDE 406_ RRQMM 411_ DPGYP 416_ KLITK 421_ NFQGI 426_ GPKID 431_ AVFYS 436_ KNKYY 441_ YFFQG 446_ SNQFE 451_ YDFLL 456_ QRITK 461_TLKSN
1: May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3