Glial cell line-derived neurotrophic factor (hGDNF) (Astrocyte-derived trophic factor) (ATF)
1_MKLWD 6_ VVAVC 11_ LVLLH 16_ TASAF 21_ PLPAG 26_ KRPPE 31_ APAED 36_ RSLGR 41_ RRAPF 46_ ALSSD 51_ SNMPE 56_ DYPDQ 61_ FDDVM 66_ DFIQA 71_ TIKRL 76_ KRSPD 81_ KQMAV 86_ LPRRE 91_ RNRQA 96_ AAANP 101_ ENSRG 106_ KGRRG 111_ QRGKN 116_ RGCVL 121_ TAIHL 126_ NVTDL 131_ GLGYE 136_ TKEEL 141_ IFRYC 146_ SGSCD 151_ AAETT 156_ YDKIL 161_ KNLSR 166_ NRRLV 171_ SDKVG 176_ QACCR 181_ PIAFD 186_ DDLSF 191_ LDDNL 196_ VYHIL 201_ RKHSA 206_KRCGC
1: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:8493557). Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor (PubMed:10829012, PubMed:25242331, PubMed:31535977). Involved in the development of the neural crest (PubMed:15242795)