Thrombopoietin receptor (TPO-R) (Myeloproliferative leukemia protein) (Proto-oncogene c-Mpl) (CD antigen CD110)
1_MPSWA 6_ LFMVT 11_ SCLLL 16_ APQNL 21_ AQVSS 26_ QDVSL 31_ LASDS 36_ EPLKC 41_ FSRTF 46_ EDLTC 51_ FWDEE 56_ EAAPS 61_ GTYQL 66_ LYAYP 71_ REKPR 76_ ACPLS 81_ SQSMP 86_ HFGTR 91_ YVCQF 96_ PDQEE 101_ VRLFF 106_ PLHLW 111_ VKNVF 116_ LNQTR 121_ TQRVL 126_ FVDSV 131_ GLPAP 136_ PSIIK 141_ AMGGS 146_ QPGEL 151_ QISWE 156_ EPAPE 161_ ISDFL 166_ RYELR 171_ YGPRD 176_ PKNST 181_ GPTVI 186_ QLIAT 191_ ETCCP 196_ ALQRP 201_ HSASA 206_ LDQSP 211_ CAQPT 216_ MPWQD 221_ GPKQT 226_ SPSRE 231_ ASALT 236_ AEGGS 241_ CLISG 246_ LQPGN 251_ SYWLQ 256_ LRSEP 261_ DGISL 266_ GGSWG 271_ SWSLP 276_ VTVDL 281_ PGDAV 286_ ALGLQ 291_ CFTLD 296_ LKNVT 301_ CQWQQ 306_ QDHAS 311_ SQGFF 316_ YHSRA 321_ RCCPR 326_ DRYPI 331_ WENCE 336_ EEEKT 341_ NPGLQ 346_ TPQFS 351_ RCHFK 356_ SRNDS 361_ IIHIL 366_ VEVTT 371_ APGTV 376_ HSYLG 381_ SPFWI 386_ HQAVR 391_ LPTPN 396_ LHWRE 401_ ISSGH 406_ LELEW 411_ QHPSS 416_ WAAQE 421_ TCYQL 426_ RYTGE 431_ GHQDW 436_ KVLEP 441_ PLGAR 446_ GGTLE 451_ LRPRS 456_ RYRLQ 461_ LRARL 466_ NGPTY 471_ QGPWS 476_ SWSDP 481_ TRVET 486_ ATETA 491_ WISLV 496_ TALHL 501_ VLGLS 506_ AVLGL 511_ LLLRW 516_ QFPAH 521_ YRRLR 526_ HALWP 531_ SLPDL 536_ HRVLG 541_ QYLRD 546_ TAALS 551_ PPKAT 556_ VSDTC 561_ EEVEP 566_ SLLEI 571_ LPKSS 576_ ERTPL 581_ PLCSS 586_ QAQMD 591_ YRRLQ 596_ PSCLG 601_ TMPLS 606_ VCPPM 611_ AESGS 616_ CCTTH 621_ IANHS 626_YLPLS
1: Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation. Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K (PubMed:15899890, PubMed:37633268). In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production