Proteasome subunit beta type-10 (EC 3.4.25.1) (Low molecular mass protein 10) (Macropain subunit MECl-1) (Multicatalytic endopeptidase complex subunit MECl-1) (Proteasome MECl-1) (Proteasome subunit beta-2i)
1_MLKPA 6_ LEPRG 11_ GFSFE 16_ NCQRN 21_ ASLER 26_ VLPGL 31_ KVPHA 36_ RKTGT 41_ TIAGL 46_ VFQDG 51_ VILGA 56_ DTRAT 61_ NDSVV 66_ ADKSC 71_ EKIHF 76_ IAPKI 81_ YCCGA 86_ GVAAD 91_ AEMTT 96_ RMVAS 101_ KMELH 106_ ALSTG 111_ REPRV 116_ ATVTR 121_ ILRQT 126_ LFRYQ 131_ GHVGA 136_ SLIVG 141_ GVDLT 146_ GPQLY 151_ GVHPH 156_ GSYSR 161_ LPFTA 166_ LGSGQ 171_ DAALA 176_ VLEDR 181_ FQPNM 186_ TLEAA 191_ QGLLV 196_ EAVTA 201_ GILGD 206_ LGSGG 211_ NVDAC 216_ VITKT 221_ GAKLL 226_ RTLSS 231_ PTEPV 236_ KRSGR 241_ YHFVP 246_ GTTAV 251_ LTQTV 256_ KPLTL 261_ ELVEE 266_TVQAM
1: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides