von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)
1_MPRRA 6_ ENWDE 11_ AEVGA 16_ EEAGV 21_ EEYGP 26_ EEDGG 31_ EESGA 36_ EESGP 41_ EESGP 46_ EELGA 51_ EEEME 56_ AGRPR 61_ PVLRS 66_ VNSRE 71_ PSQVI 76_ FCNRS 81_ PRVVL 86_ PVWLN 91_ FDGEP 96_ QPYPT 101_ LPPGT 106_ GRRIH 111_ SYRGH 116_ LWLFR 121_ DAGTH 126_ DGLLV 131_ NQTEL 136_ FVPSL 141_ NVDGQ 146_ PIFAN 151_ ITLPV 156_ YTLKE 161_ RCLQV 166_ VRSLV 171_ KPENY 176_ RRLDI 181_ VRSLY 186_ EDLED 191_ HPNVQ 196_ KDLER 201_ LTQER 206_IAHQR
1: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex (PubMed:10944113, PubMed:17981124, PubMed:19584355). Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions (PubMed:10944113, PubMed:17981124). Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases (PubMed:10944113, PubMed:17981124). Ubiquitinates, in an oxygen-responsive manner, ADRB2 (PubMed:19584355). Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR (PubMed:34290272)