All-trans-retinol dehydrogenase [NAD(+)] ADH7 (EC 1.1.1.105) (Alcohol dehydrogenase class 4 mu/sigma chain) (EC 1.1.1.1) (Alcohol dehydrogenase class IV mu/sigma chain) (Gastric alcohol dehydrogenase) (Omega-hydroxydecanoate dehydrogenase ADH7) (EC 1.1.1.66) (Retinol dehydrogenase)
1_MFAEI 6_ QIQDK 11_ DRMGT 16_ AGKVI 21_ KCKAA 26_ VLWEQ 31_ KQPFS 36_ IEEIE 41_ VAPPK 46_ TKEVR 51_ IKILA 56_ TGICR 61_ TDDHV 66_ IKGTM 71_ VSKFP 76_ VIVGH 81_ EATGI 86_ VESIG 91_ EGVTT 96_ VKPGD 101_ KVIPL 106_ FLPQC 111_ RECNA 116_ CRNPD 121_ GNLCI 126_ RSDIT 131_ GRGVL 136_ ADGTT 141_ RFTCK 146_ GKPVH 151_ HFMNT 156_ STFTE 161_ YTVVD 166_ ESSVA 171_ KIDDA 176_ APPEK 181_ VCLIG 186_ CGFST 191_ GYGAA 196_ VKTGK 201_ VKPGS 206_ TCVVF 211_ GLGGV 216_ GLSVI 221_ MGCKS 226_ AGASR 231_ IIGID 236_ LNKDK 241_ FEKAM 246_ AVGAT 251_ ECISP 256_ KDSTK 261_ PISEV 266_ LSEMT 271_ GNNVG 276_ YTFEV 281_ IGHLE 286_ TMIDA 291_ LASCH 296_ MNYGT 301_ SVVVG 306_ VPPSA 311_ KMLTY 316_ DPMLL 321_ FTGRT 326_ WKGCV 331_ FGGLK 336_ SRDDV 341_ PKLVT 346_ EFLAK 351_ KFDLD 356_ QLITH 361_ VLPFK 366_ KISEG 371_ FELLN 376_ SGQSI 381_RTVLT
1: Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid (PubMed:15369820, PubMed:16787387, PubMed:9600267). In vitro can also catalyze the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:15369820, PubMed:16787387). Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation (PubMed:15369820, PubMed:16787387, PubMed:9600267)