Pre-B-cell leukemia transcription factor 1 (Homeobox protein PBX1) (Homeobox protein PRL)
1_MDEQP 6_ RLMHS 11_ HAGVG 16_ MAGHP 21_ GLSQH 26_ LQDGA 31_ GGTEG 36_ EGGRK 41_ QDIGD 46_ ILQQI 51_ MTITD 56_ QSLDE 61_ AQARK 66_ HALNC 71_ HRMKP 76_ ALFNV 81_ LCEIK 86_ EKTVL 91_ SIRGA 96_ QEEEP 101_ TDPQL 106_ MRLDN 111_ MLLAE 116_ GVAGP 121_ EKGGG 126_ SAAAA 131_ AAAAA 136_ SGGAG 141_ SDNSV 146_ EHSDY 151_ RAKLS 156_ QIRQI 161_ YHTEL 166_ EKYEQ 171_ ACNEF 176_ TTHVM 181_ NLLRE 186_ QSRTR 191_ PISPK 196_ EIERM 201_ VSIIH 206_ RKFSS 211_ IQMQL 216_ KQSTC 221_ EAVMI 226_ LRSRF 231_ LDARR 236_ KRRNF 241_ NKQAT 246_ EILNE 251_ YFYSH 256_ LSNPY 261_ PSEEA 266_ KEELA 271_ KKCGI 276_ TVSQV 281_ SNWFG 286_ NKRIR 291_ YKKNI 296_ GKFQE 301_ EANIY 306_ AAKTA 311_ VTATN 316_ VSAHG 321_ SQANS 326_ PSTPN 331_ SAGSS 336_ SSFNM 341_ SNSGD 346_ LFMSV 351_ QSLNG 356_ DSYQG 361_ AQVGA 366_ NVQSQ 371_ VDTLR 376_ HVISQ 381_ TGGYS 386_ DGLAA 391_ SQMYS 396_ PQGIS 401_ ANGGW 406_ QDATT 411_ PSSVT 416_ SPTEG 421_PGSVH
1: Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 (PubMed:9191052). Binds to the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein (PubMed:9191052). Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 (PubMed:7791786, PubMed:8327485). Acts as a transcriptional activator of PF4 in complex with MEIS1 (PubMed:12609849). Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (By similarity). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (By similarity). Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (By similarity). Probably in complex with MEIS2, involved in transcriptional regulation by KLF4 (PubMed:21746878). Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (By similarity). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (By similarity)
2: As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element