60S ribosomal protein L13a (23 kDa highly basic protein) (Large ribosomal subunit protein uL13)
1_MAEVQ 6_ VLVLD 11_ GRGHL 16_ LGRLA 21_ AIVAK 26_ QVLLG 31_ RKVVV 36_ VRCEG 41_ INISG 46_ NFYRN 51_ KLKYL 56_ AFLRK 61_ RMNTN 66_ PSRGP 71_ YHFRA 76_ PSRIF 81_ WRTVR 86_ GMLPH 91_ KTKRG 96_ QAALD 101_ RLKVF 106_ DGIPP 111_ PYDKK 116_ KRMVV 121_ PAALK 126_ VVRLK 131_ PTRKF 136_ AYLGR 141_ LAHEV 146_ GWKYQ 151_ AVTAT 156_ LEEKR 161_ KEKAK 166_ IHYRK 171_ KKQLM 176_ RLRKQ 181_ AEKNV 186_ EKKID 191_ KYTEV 196_LKTHG
1: Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (PubMed:14567916, PubMed:17218275, PubMed:23636399, PubMed:32669547). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (PubMed:23071094). Involved in methylation of rRNA (PubMed:17921318)