Signal transducer and activator of transcription 3 (Acute-phase response factor)
1_MAQWN 6_ QLQQL 11_ DTRYL 16_ EQLHQ 21_ LYSDS 26_ FPMEL 31_ RQFLA 36_ PWIES 41_ QDWAY 46_ AASKE 51_ SHATL 56_ VFHNL 61_ LGEID 66_ QQYSR 71_ FLQES 76_ NVLYQ 81_ HNLRR 86_ IKQFL 91_ QSRYL 96_ EKPME 101_ IARIV 106_ ARCLW 111_ EESRL 116_ LQTAA 121_ TAAQQ 126_ GGQAN 131_ HPTAA 136_ VVTEK 141_ QQMLE 146_ QHLQD 151_ VRKRV 156_ QDLEQ 161_ KMKVV 166_ ENLQD 171_ DFDFN 176_ YKTLK 181_ SQGDM 186_ QDLNG 191_ NNQSV 196_ TRQKM 201_ QQLEQ 206_ MLTAL 211_ DQMRR 216_ SIVSE 221_ LAGLL 226_ SAMEY 231_ VQKTL 236_ TDEEL 241_ ADWKR 246_ RQQIA 251_ CIGGP 256_ PNICL 261_ DRLEN 266_ WITSL 271_ AESQL 276_ QTRQQ 281_ IKKLE 286_ ELQQK 291_ VSYKG 296_ DPIVQ 301_ HRPML 306_ EERIV 311_ ELFRN 316_ LMKSA 321_ FVVER 326_ QPCMP 331_ MHPDR 336_ PLVIK 341_ TGVQF 346_ TTKVR 351_ LLVKF 356_ PELNY 361_ QLKIK 366_ VCIDK 371_ DSGDV 376_ AALRG 381_ SRKFN 386_ ILGTN 391_ TKVMN 396_ MEESN 401_ NGSLS 406_ AEFKH 411_ LTLRE 416_ QRCGN 421_ GGRAN 426_ CDASL 431_ IVTEE 436_ LHLIT 441_ FETEV 446_ YHQGL 451_ KIDLE 456_ THSLP 461_ VVVIS 466_ NICQM 471_ PNAWA 476_ SILWY 481_ NMLTN 486_ NPKNV 491_ NFFTK 496_ PPIGT 501_ WDQVA 506_ EVLSW 511_ QFSST 516_ TKRGL 521_ SIEQL 526_ TTLAE 531_ KLLGP 536_ GVNYS 541_ GCQIT 546_ WAKFC 551_ KENMA 556_ GKGFS 561_ FWVWL 566_ DNIID 571_ LVKKY 576_ ILALW 581_ NEGYI 586_ MGFIS 591_ KERER 596_ AILST 601_ KPPGT 606_ FLLRF 611_ SESSK 616_ EGGVT 621_ FTWVE 626_ KDISG 631_ KTQIQ 636_ SVEPY 641_ TKQQL 646_ NNMSF 651_ AEIIM 656_ GYKIM 661_ DATNI 666_ LVSPL 671_ VYLYP 676_ DIPKE 681_ EAFGK 686_ YCRPE 691_ SQEHP 696_ EADPG 701_ SAAPY 706_ LKTKF 711_ ICVTP 716_ TTCSN 721_ TIDLP 726_ MSPRT 731_ LDSLM 736_ QFGNN 741_ GEGAE 746_ PSAGG 751_ QFESL 756_ TFDME 761_LTSEC
1: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18242580, PubMed:18782771, PubMed:22306293, PubMed:23084476, PubMed:28262505, PubMed:32929201, PubMed:38404237). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:15653507, PubMed:16285960, PubMed:17344214, PubMed:18782771, PubMed:28262505, PubMed:32929201). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation (PubMed:28065600, PubMed:28262505). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity)