Ubiquitin carboxyl-terminal hydrolase 8 (EC 3.4.19.12) (Deubiquitinating enzyme 8) (Ubiquitin isopeptidase Y) (hUBPy) (Ubiquitin thioesterase 8) (Ubiquitin-specific-processing protease 8)
1_MPAVA 6_ SVPKE 11_ LYLSS 16_ SLKDL 21_ NKKTE 26_ VKPEK 31_ ISTKS 36_ YVHSA 41_ LKIFK 46_ TAEEC 51_ RLDRD 56_ EERAY 61_ VLYMK 66_ YVTVY 71_ NLIKK 76_ RPDFK 81_ QQQDY 86_ FHSIL 91_ GPGNI 96_ KKAVE 101_ EAERL 106_ SESLK 111_ LRYEE 116_ AEVRK 121_ KLEEK 126_ DRQEE 131_ AQRLQ 136_ QKRQE 141_ TGRED 146_ GGTLA 151_ KGSLE 156_ NVLDS 161_ KDKTQ 166_ KSNGE 171_ KNEKC 176_ ETKEK 181_ GAITA 186_ KELYT 191_ MMTDK 196_ NISLI 201_ IMDAR 206_ RMQDY 211_ QDSCI 216_ LHSLS 221_ VPEEA 226_ ISPGV 231_ TASWI 236_ EAHLP 241_ DDSKD 246_ TWKKR 251_ GNVEY 256_ VVLLD 261_ WFSSA 266_ KDLQI 271_ GTTLR 276_ SLKDA 281_ LFKWE 286_ SKTVL 291_ RNEPL 296_ VLEGG 301_ YENWL 306_ LCYPQ 311_ YTTNA 316_ KVTPP 321_ PRRQN 326_ EEVSI 331_ SLDFT 336_ YPSLE 341_ ESIPS 346_ KPAAQ 351_ TPPAS 356_ IEVDE 361_ NIELI 366_ SGQNE 371_ RMGPL 376_ NISTP 381_ VEPVA 386_ ASKSD 391_ VSPII 396_ QPVPS 401_ IKNVP 406_ QIDRT 411_ KKPAV 416_ KLPEE 421_ HRIKS 426_ ESTNH 431_ EQQSP 436_ QSGKV 441_ IPDRS 446_ TKPVV 451_ FSPTL 456_ MLTDE 461_ EKARI 466_ HAETA 471_ LLMEK 476_ NKQEK 481_ ELRER 486_ QQEEQ 491_ KEKLR 496_ KEEQE 501_ QKAKK 506_ KQEAE 511_ ENEIT 516_ EKQQK 521_ AKEEM 526_ EKKES 531_ EQAKK 536_ EDKET 541_ SAKRG 546_ KEITG 551_ VKRQS 556_ KSEHE 561_ TSDAK 566_ KSVED 571_ RGKRC 576_ PTPEI 581_ QKKST 586_ GDVPH 591_ TSVTG 596_ DSGSG 601_ KPFKI 606_ KGQPE 611_ SGILR 616_ TGTFR 621_ EDTDD 626_ TERNK 631_ AQREP 636_ LTRAR 641_ SEEMG 646_ RIVPG 651_ LPSGW 656_ AKFLD 661_ PITGT 666_ FRYYH 671_ SPTNT 676_ VHMYP 681_ PEMAP 686_ SSAPP 691_ STPPT 696_ HKAKP 701_ QIPAE 706_ RDREP 711_ SKLKR 716_ SYSSP 721_ DITQA 726_ IQEEE 731_ KRKPT 736_ VTPTV 741_ NRENK 746_ PTCYP 751_ KAEIS 756_ RLSAS 761_ QIRNL 766_ NPVFG 771_ GSGPA 776_ LTGLR 781_ NLGNT 786_ CYMNS 791_ ILQCL 796_ CNAPH 801_ LADYF 806_ NRNCY 811_ QDDIN 816_ RSNLL 821_ GHKGE 826_ VAEEF 831_ GIIMK 836_ ALWTG 841_ QYRYI 846_ SPKDF 851_ KITIG 856_ KINDQ 861_ FAGYS 866_ QQDSQ 871_ ELLLF 876_ LMDGL 881_ HEDLN 886_ KADNR 891_ KRYKE 896_ ENNDH 901_ LDDFK 906_ AAEHA 911_ WQKHK 916_ QLNES 921_ IIVAL 926_ FQGQF 931_ KSTVQ 936_ CLTCH 941_ KKSRT 946_ FEAFM 951_ YLSLP 956_ LASTS 961_ KCTLQ 966_ DCLRL 971_ FSKEE 976_ KLTDN 981_ NRFYC 986_ SHCRA 991_ RRDSL 996_ KKIEI 1001_ WKLPP 1006_ VLLVH 1011_ LKRFS 1016_ YDGRW 1021_ KQKLQ 1026_ TSVDF 1031_ PLENL 1036_ DLSQY 1041_ VIGPK 1046_ NNLKK 1051_ YNLFS 1056_ VSNHY 1061_ GGLDG 1066_ GHYTA 1071_ YCKNA 1076_ ARQRW 1081_ FKFDD 1086_ HEVSD 1091_ ISVSS 1096_ VKSSA 1101_ AYILF 1106_ YTSLG 1111_PRVTD
1: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controls tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1. Deubiquitinates BACE1 which inhibits BACE1 lysosomal degradation and modulates BACE-mediated APP cleavage and amyloid-beta formation (PubMed:27302062)