Peroxisomal biogenesis factor 19 (33 kDa housekeeping protein) (Peroxin-19) (Peroxisomal farnesylated protein)
1_MAAAE 6_ EGCSV 11_ GAEAD 16_ RELEE 21_ LLESA 26_ LDDFD 31_ KAKPS 36_ PAPPS 41_ TTTAP 46_ DASGP 51_ QKRSP 56_ GDTAK 61_ DALFA 66_ SQEKF 71_ FQELF 76_ DSELA 81_ SQATA 86_ EFEKA 91_ MKELA 96_ EEEPH 101_ LVEQF 106_ QKLSE 111_ AAGRV 116_ GSDMT 121_ SQQEF 126_ TSCLK 131_ ETLSG 136_ LAKNA 141_ TDLQN 146_ SSMSE 151_ EELTK 156_ AMEGL 161_ GMDEG 166_ DGEGN 171_ ILPIM 176_ QSIMQ 181_ NLLSK 186_ DVLYP 191_ SLKEI 196_ TEKYP 201_ EWLQS 206_ HRESL 211_ PPEQF 216_ EKYQE 221_ QHSVM 226_ CKICE 231_ QFEAE 236_ TPTDS 241_ ETTQK 246_ ARFEM 251_ VLDLM 256_ QQLQD 261_ LGHPP 266_ KELAG 271_ EMPPG 276_ LNFDL 281_ DALNL 286_ SGPPG 291_ASGEQ
1: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53