Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Cytosolic malate dehydrogenase) (Diiodophenylpyruvate reductase) (EC 1.1.1.96)
1_MSEPI 6_ RVLVT 11_ GAAGQ 16_ IAYSL 21_ LYSIG 26_ NGSVF 31_ GKDQP 36_ IILVL 41_ LDITP 46_ MMGVL 51_ DGVLM 56_ ELQDC 61_ ALPLL 66_ KDVIA 71_ TDKED 76_ VAFKD 81_ LDVAI 86_ LVGSM 91_ PRREG 96_ MERKD 101_ LLKAN 106_ VKIFK 111_ SQGAA 116_ LDKYA 121_ KKSVK 126_ VIVVG 131_ NPANT 136_ NCLTA 141_ SKSAP 146_ SIPKE 151_ NFSCL 156_ TRLDH 161_ NRAKA 166_ QIALK 171_ LGVTA 176_ NDVKN 181_ VIIWG 186_ NHSST 191_ QYPDV 196_ NHAKV 201_ KLQGK 206_ EVGVY 211_ EALKD 216_ DSWLK 221_ GEFVT 226_ TVQQR 231_ GAAVI 236_ KARKL 241_ SSAMS 246_ AAKAI 251_ CDHVR 256_ DIWFG 261_ TPEGE 266_ FVSMG 271_ VISDG 276_ NSYGV 281_ PDDLL 286_ YSFPV 291_ VIKNK 296_ TWKFV 301_ EGLPI 306_ NDFSR 311_ EKMDL 316_ TAKEL 321_ TEEKE 326_SAFEF
1: Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073)