Melanocyte protein PMEL (ME20-M) (ME20M) (Melanocyte protein Pmel 17) (Melanocytes lineage-specific antigen GP100) (Melanoma-associated ME20 antigen) (P1) (P100) (Premelanosome protein) (Silver locus protein homolog) [Cleaved into: M-alpha (95 kDa melanocyte-specific secreted glycoprotein) (P26) (Secreted melanoma-associated ME20 antigen) (ME20-S) (ME20S); M-beta]
1_MDLVL 6_ KRCLL 11_ HLAVI 16_ GALLA 21_ VGATK 26_ VPRNQ 31_ DWLGV 36_ SRQLR 41_ TKAWN 46_ RQLYP 51_ EWTEA 56_ QRLDC 61_ WRGGQ 66_ VSLKV 71_ SNDGP 76_ TLIGA 81_ NASFS 86_ IALNF 91_ PGSQK 96_ VLPDG 101_ QVIWV 106_ NNTII 111_ NGSQV 116_ WGGQP 121_ VYPQE 126_ TDDAC 131_ IFPDG 136_ GPCPS 141_ GSWSQ 146_ KRSFV 151_ YVWKT 156_ WGQYW 161_ QVLGG 166_ PVSGL 171_ SIGTG 176_ RAMLG 181_ THTME 186_ VTVYH 191_ RRGSR 196_ SYVPL 201_ AHSSS 206_ AFTIT 211_ DQVPF 216_ SVSVS 221_ QLRAL 226_ DGGNK 231_ HFLRN 236_ QPLTF 241_ ALQLH 246_ DPSGY 251_ LAEAD 256_ LSYTW 261_ DFGDS 266_ SGTLI 271_ SRALV 276_ VTHTY 281_ LEPGP 286_ VTAQV 291_ VLQAA 296_ IPLTS 301_ CGSSP 306_ VPGTT 311_ DGHRP 316_ TAEAP 321_ NTTAG 326_ QVPTT 331_ EVVGT 336_ TPGQA 341_ PTAEP 346_ SGTTS 351_ VQVPT 356_ TEVIS 361_ TAPVQ 366_ MPTAE 371_ STGMT 376_ PEKVP 381_ VSEVM 386_ GTTLA 391_ EMSTP 396_ EATGM 401_ TPAEV 406_ SIVVL 411_ SGTTA 416_ AQVTT 421_ TEWVE 426_ TTARE 431_ LPIPE 436_ PEGPD 441_ ASSIM 446_ STESI 451_ TGSLG 456_ PLLDG 461_ TATLR 466_ LVKRQ 471_ VPLDC 476_ VLYRY 481_ GSFSV 486_ TLDIV 491_ QGIES 496_ AEILQ 501_ AVPSG 506_ EGDAF 511_ ELTVS 516_ CQGGL 521_ PKEAC 526_ MEISS 531_ PGCQP 536_ PAQRL 541_ CQPVL 546_ PSPAC 551_ QLVLH 556_ QILKG 561_ GSGTY 566_ CLNVS 571_ LADTN 576_ SLAVV 581_ STQLI 586_ MPGQE 591_ AGLGQ 596_ VPLIV 601_ GILLV 606_ LMAVV 611_ LASLI 616_ YRRRL 621_ MKQDF 626_ SVPQL 631_ PHSSS 636_ HWLRL 641_ PRIFC 646_ SCPIG 651_ ENSPL 656_LSGQQ
1: Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation. The maturation of unpigmented premelanosomes from stage I to II is marked by assembly of processed amyloidogenic fragments into parallel fibrillar sheets, which elongate the vesicle into a striated ellipsoidal shape. In pigmented stage III and IV melanosomes, the amyloid matrix serves as a platform where eumelanin precursors accumulate at high local concentrations for pigment formation. May prevent pigmentation-associated toxicity by sequestering toxic reaction intermediates of eumelanin biosynthesis pathway
2: Represents a potent melanoma-specific antigen. Among melanoma non-mutated self-peptides, G9-154 (KTWGQYWQV), G9-209 (ITDQVPFSV) and G9-280 (YLEPGPVTA), appear to act as immunodominant common epitopes that stimulate anti-tumor immune response mediated by HLA-A-restricted cytotoxic T cells