Cyclin-F (F-box only protein 1)
1_MGSGG 6_ VVHCR 11_ CAKCF 16_ CYPTK 21_ RRIRR 26_ RPRNL 31_ TILSL 36_ PEDVL 41_ FHILK 46_ WLSVE 51_ DILAV 56_ RAVHS 61_ QLKDL 66_ VDNHA 71_ SVWAC 76_ ASFQE 81_ LWPSP 86_ GNLKL 91_ FERAA 96_ EKGNF 101_ EAAVK 106_ LGIAY 111_ LYNEG 116_ LSVSD 121_ EARAE 126_ VNGLK 131_ ASRFF 136_ SLAER 141_ LNVGA 146_ APFIW 151_ LFIRP 156_ PWSVS 161_ GSCCK 166_ AVVHE 171_ SLRAE 176_ CQLQR 181_ THKAS 186_ ILHCL 191_ GRVLS 196_ LFEDE 201_ EKQQQ 206_ AHDLF 211_ EEAAH 216_ QGCLT 221_ SSYLL 226_ WESDR 231_ RTDVS 236_ DPGRC 241_ LHSFR 246_ KLRDY 251_ AAKGC 256_ WEAQL 261_ SLAKA 266_ CANAN 271_ QLGLE 276_ VRASS 281_ EIVCQ 286_ LFQAS 291_ QAVSK 296_ QQVFS 301_ VQKGL 306_ NDTMR 311_ YILID 316_ WLVEV 321_ ATMKD 326_ FTSLC 331_ LHLTV 336_ ECVDR 341_ YLRRR 346_ LVPRY 351_ RLQLL 356_ GIACM 361_ VICTR 366_ FISKE 371_ ILTIR 376_ EAVWL 381_ TDNTY 386_ KYEDL 391_ VRMMG 396_ EIVSA 401_ LEGKI 406_ RVPTV 411_ VDYKE 416_ VLLTL 421_ VPVEL 426_ RTQHL 431_ CSFLC 436_ ELSLL 441_ HTSLS 446_ AYAPA 451_ RLAAA 456_ ALLLA 461_ RLTHG 466_ QTQPW 471_ TTQLW 476_ DLTGF 481_ SYEDL 486_ IPCVL 491_ SLHKK 496_ CFHDD 501_ APKDY 506_ RQVSL 511_ TAVKQ 516_ RFEDK 521_ RYGEI 526_ SQEEV 531_ LSYSQ 536_ LCAAL 541_ GVTQD 546_ SPDPP 551_ TFLST 556_ GEIHA 561_ FLSSP 566_ SGRRT 571_ KRKRE 576_ NSLQE 581_ DRGSF 586_ VTTPT 591_ AELSS 596_ QEETL 601_ LGSFL 606_ DWSLD 611_ CCSGY 616_ EGDQE 621_ SEGEK 626_ EGDVT 631_ APSGI 636_ LDVTV 641_ VYLNP 646_ EQHCC 651_ QESSD 656_ EEACP 661_ EDKGP 666_ QDPQA 671_ LALDT 676_ QIPAT 681_ PGPKP 686_ LVRTS 691_ REPGK 696_ DVTTS 701_ GYSSV 706_ STASP 711_ TSSVD 716_ GGLGA 721_ LPQPT 726_ SVLSL 731_ DSDSH 736_ TQPCH 741_ HQARK 746_ SCLQC 751_ RPPSP 756_ PESSV 761_ PQQQV 766_ KRINL 771_ CIHSE 776_ EEDMN 781_LGLVR
1: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:20596027, PubMed:22632967, PubMed:26818844, PubMed:27080313, PubMed:27653696, PubMed:28852778). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (PubMed:20596027, PubMed:26818844, PubMed:27653696, PubMed:8706131). Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability (PubMed:20596027, PubMed:22632967, PubMed:26818844, PubMed:27653696). Mediates the ubiquitination and proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication (PubMed:20596027). In G2, mediates the ubiquitination and subsequent degradation of ribonucleotide reductase RRM2, thereby maintaining a balanced pool of dNTPs and genome integrity (PubMed:22632967). In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability (PubMed:26818844). Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry (PubMed:27653696). May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB (PubMed:25557911)