Eukaryotic translation initiation factor 2 subunit 3 (EC 3.6.5.3) (Eukaryotic translation initiation factor 2 subunit gamma X) (eIF-2-gamma X) (eIF-2gX)
1_MAGGE 6_ AGVTL 11_ GQPHL 16_ SRQDL 21_ TTLDV 26_ TKLTP 31_ LSHEV 36_ ISRQA 41_ TINIG 46_ TIGHV 51_ AHGKS 56_ TVVKA 61_ ISGVH 66_ TVRFK 71_ NELER 76_ NITIK 81_ LGYAN 86_ AKIYK 91_ LDDPS 96_ CPRPE 101_ CYRSC 106_ GSSTP 111_ DEFPT 116_ DIPGT 121_ KGNFK 126_ LVRHV 131_ SFVDC 136_ PGHDI 141_ LMATM 146_ LNGAA 151_ VMDAA 156_ LLLIA 161_ GNESC 166_ PQPQT 171_ SEHLA 176_ AIEIM 181_ KLKHI 186_ LILQN 191_ KIDLV 196_ KESQA 201_ KEQYE 206_ QILAF 211_ VQGTV 216_ AEGAP 221_ IIPIS 226_ AQLKY 231_ NIEVV 236_ CEYIV 241_ KKIPV 246_ PPRDF 251_ TSEPR 256_ LIVIR 261_ SFDVN 266_ KPGCE 271_ VDDLK 276_ GGVAG 281_ GSILK 286_ GVLKV 291_ GQEIE 296_ VRPGI 301_ VSKDS 306_ EGKLM 311_ CKPIF 316_ SKIVS 321_ LFAEH 326_ NDLQY 331_ AAPGG 336_ LIGVG 341_ TKIDP 346_ TLCRA 351_ DRMVG 356_ QVLGA 361_ VGALP 366_ EIFTE 371_ LEISY 376_ FLLRR 381_ LLGVR 386_ TEGDK 391_ KAAKV 396_ QKLSK 401_ NEVLM 406_ VNIGS 411_ LSTGG 416_ RVSAV 421_ KADLG 426_ KIVLT 431_ NPVCT 436_ EVGEK 441_ IALSR 446_ RVEKH 451_ WRLIG 456_ WGQIR 461_ RGVTI 466_KPTVD
1: Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC) (By similarity). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex (By similarity). In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity)