DNA-binding protein inhibitor ID-1 (Class B basic helix-loop-helix protein 24) (bHLHb24) (Inhibitor of DNA binding 1) (Inhibitor of differentiation 1)
1_MKVAS 6_ GSTAT 11_ AAAGP 16_ SCALK 21_ AGKTA 26_ SGAGE 31_ VVRCL 36_ SEQSV 41_ AISRC 46_ AGGAG 51_ ARLPA 56_ LLDEQ 61_ QVNVL 66_ LYDMN 71_ GCYSR 76_ LKELV 81_ PTLPQ 86_ NRKVS 91_ KVEIL 96_ QHVID 101_ YIRDL 106_ QLELN 111_ SESEV 116_ GTPGG 121_ RGLPV 126_ RAPLS 131_ TLNGE 136_ ISALT 141_ AEAAC 146_VPADD
1: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity)