Delta-type opioid receptor (D-OR-1) (DOR-1)
1_MEPAP 6_ SAGAE 11_ LQPPL 16_ FANAS 21_ DAYPS 26_ ACPSA 31_ GANAS 36_ GPPGA 41_ RSASS 46_ LALAI 51_ AITAL 56_ YSAVC 61_ AVGLL 66_ GNVLV 71_ MFGIV 76_ RYTKM 81_ KTATN 86_ IYIFN 91_ LALAD 96_ ALATS 101_ TLPFQ 106_ SAKYL 111_ METWP 116_ FGELL 121_ CKAVL 126_ SIDYY 131_ NMFTS 136_ IFTLT 141_ MMSVD 146_ RYIAV 151_ CHPVK 156_ ALDFR 161_ TPAKA 166_ KLINI 171_ CIWVL 176_ ASGVG 181_ VPIMV 186_ MAVTR 191_ PRDGA 196_ VVCML 201_ QFPSP 206_ SWYWD 211_ TVTKI 216_ CVFLF 221_ AFVVP 226_ ILIIT 231_ VCYGL 236_ MLLRL 241_ RSVRL 246_ LSGSK 251_ EKDRS 256_ LRRIT 261_ RMVLV 266_ VVGAF 271_ VVCWA 276_ PIHIF 281_ VIVWT 286_ LVDID 291_ RRDPL 296_ VVAAL 301_ HLCIA 306_ LGYAN 311_ SSLNP 316_ VLYAF 321_ LDENF 326_ KRCFR 331_ QLCRK 336_ PCGRP 341_ DPSSF 346_ SRARE 351_ ATARE 356_ RVTAC 361_ TPSDG 366_PGGGA
1: G-protein coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine