Nociceptin receptor (Kappa-type 3 opioid receptor) (KOR-3) (Orphanin FQ receptor)
1_MEPLF 6_ PAPFW 11_ EVIYG 16_ SHLQG 21_ NLSLL 26_ SPNHS 31_ LLPPH 36_ LLLNA 41_ SHGAF 46_ LPLGL 51_ KVTIV 56_ GLYLA 61_ VCVGG 66_ LLGNC 71_ LVMYV 76_ ILRHT 81_ KMKTA 86_ TNIYI 91_ FNLAL 96_ ADTLV 101_ LLTLP 106_ FQGTD 111_ ILLGF 116_ WPFGN 121_ ALCKT 126_ VIAID 131_ YYNMF 136_ TSTFT 141_ LTAMS 146_ VDRYV 151_ AICHP 156_ IRALD 161_ VRTSS 166_ KAQAV 171_ NVAIW 176_ ALASV 181_ VGVPV 186_ AIMGS 191_ AQVED 196_ EEIEC 201_ LVEIP 206_ TPQDY 211_ WGPVF 216_ AICIF 221_ LFSFI 226_ VPVLV 231_ ISVCY 236_ SLMIR 241_ RLRGV 246_ RLLSG 251_ SREKD 256_ RNLRR 261_ ITRLV 266_ LVVVA 271_ VFVGC 276_ WTPVQ 281_ VFVLA 286_ QGLGV 291_ QPSSE 296_ TAVAI 301_ LRFCT 306_ ALGYV 311_ NSCLN 316_ PILYA 321_ FLDEN 326_ FKACF 331_ RKFCC 336_ ASALR 341_ RDVQV 346_ SDRVR 351_ SIAKD 356_ VALAC 361_KTSET
1: G-protein coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin