Aquaporin-2 (AQP-2) (ADH water channel) (Aquaporin-CD) (AQP-CD) (Collecting duct water channel protein) (WCH-CD) (Water channel protein for renal collecting duct)
1_MWELR 6_ SIAFS 11_ RAVFA 16_ EFLAT 21_ LLFVF 26_ FGLGS 31_ ALNWP 36_ QALPS 41_ VLQIA 46_ MAFGL 51_ GIGTL 56_ VQALG 61_ HISGA 66_ HINPA 71_ VTVAC 76_ LVGCH 81_ VSVLR 86_ AAFYV 91_ AAQLL 96_ GAVAG 101_ AALLH 106_ EITPA 111_ DIRGD 116_ LAVNA 121_ LSNST 126_ TAGQA 131_ VTVEL 136_ FLTLQ 141_ LVLCI 146_ FASTD 151_ ERRGE 156_ NPGTP 161_ ALSIG 166_ FSVAL 171_ GHLLG 176_ IHYTG 181_ CSMNP 186_ ARSLA 191_ PAVVT 196_ GKFDD 201_ HWVFW 206_ IGPLV 211_ GAILG 216_ SLLYN 221_ YVLFP 226_ PAKSL 231_ SERLA 236_ VLKGL 241_ EPDTD 246_ WEERE 251_ VRRRQ 256_ SVELH 261_ SPQSL 266_PRGTK
1: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:15509592, PubMed:7510718, PubMed:7524315, PubMed:8140421, PubMed:8584435). Plays an essential role in renal water homeostasis (PubMed:15509592, PubMed:7524315, PubMed:8140421). Could also be permeable to glycerol (PubMed:8584435)