Eukaryotic translation initiation factor 2D (eIF2d) (Hepatocellular carcinoma-associated antigen 56) (Ligatin)
1_MFAKA 6_ FRVKS 11_ NTAIK 16_ GSDRR 21_ KLRAD 26_ VTTAF 31_ PTLGT 36_ DQVSE 41_ LVPGK 46_ EELNI 51_ VKLYA 56_ HKGDA 61_ VTVYV 66_ SGGNP 71_ ILFEL 76_ EKNLY 81_ PTVYT 86_ LWSYP 91_ DLLPT 96_ FTTWP 101_ LVLEK 106_ LVGGA 111_ DLMLP 116_ GLVMP 121_ PAGLP 126_ QVQKG 131_ DLCAI 136_ SLVGN 141_ RAPVA 146_ IGVAA 151_ MSTAE 156_ MLTSG 161_ LKGRG 166_ FSVLH 171_ TYQDH 176_ LWRSG 181_ NKSSP 186_ PSIAP 191_ LALDS 196_ ADLSE 201_ EKGSV 206_ QMDST 211_ LQGDM 216_ RHMTL 221_ EGEEE 226_ NGEVH 231_ QARED 236_ KSLSE 241_ APEDT 246_ STRGL 251_ NQDST 256_ DSKTL 261_ QEQMD 266_ ELLQQ 271_ CFLHA 276_ LKCRV 281_ KKADL 286_ PLLTS 291_ TFLGS 296_ HMFSC 301_ CPEGR 306_ QLDIK 311_ KSSYK 316_ KLSKF 321_ LQQMQ 326_ QEQII 331_ QVKEL 336_ SKGVE 341_ SIVAV 346_ DWKHP 351_ RITSF 356_ VIPEP 361_ SPTSQ 366_ TIQEG 371_ SREQP 376_ YHPPD 381_ IKPLY 386_ CVPAS 391_ MTLLF 396_ QESGH 401_ KKGSF 406_ LEGSE 411_ VRTIV 416_ INYAK 421_ KNDLV 426_ DADNK 431_ NLVRL 436_ DPILC 441_ DCILE 446_ KNEQH 451_ TVMKL 456_ PWDSL 461_ LTRCL 466_ EKLQP 471_ AYQVT 476_ LPGQE 481_ PIVKK 486_ GRICP 491_ IDITL 496_ AQRAS 501_ NKKVT 506_ VVRNL 511_ EAYGL 516_ DPYSV 521_ AAILQ 526_ QRCQA 531_ STTVN 536_ PAPGA 541_ KDSLQ 546_ VQIQG 551_ NQVHH 556_ LGWLL 561_ LEEYQ 566_ LPRKH 571_ IQGLE 576_KALKP
1: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits