Regulator of G-protein signaling 2 (RGS2) (Cell growth-inhibiting gene 31 protein) (G0/G1 switch regulatory protein 8)
1_MQSAM 6_ FLAVQ 11_ HDCRP 16_ MDKSA 21_ GSGHK 26_ SEEKR 31_ EKMKR 36_ TLLKD 41_ WKTRL 46_ SYFLQ 51_ NSSTP 56_ GKPKT 61_ GKKSK 66_ QQAFI 71_ KPSPE 76_ EAQLW 81_ SEAFD 86_ ELLAS 91_ KYGLA 96_ AFRAF 101_ LKSEF 106_ CEENI 111_ EFWLA 116_ CEDFK 121_ KTKSP 126_ QKLSS 131_ KARKI 136_ YTDFI 141_ EKEAP 146_ KEINI 151_ DFQTK 156_ TLIAQ 161_ NIQEA 166_ TSGCF 171_ TTAQK 176_ RVYSL 181_ MENNS 186_ YPRFL 191_ ESEFY 196_ QDLCK 201_ KPQIT 206_TEPHA
1: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320)