Protein Wnt-5a
1_MKKSI 6_ GILSP 11_ GVALG 16_ MAGSA 21_ MSSKF 26_ FLVAL 31_ AIFFS 36_ FAQVV 41_ IEANS 46_ WWSLG 51_ MNNPV 56_ QMSEV 61_ YIIGA 66_ QPLCS 71_ QLAGL 76_ SQGQK 81_ KLCHL 86_ YQDHM 91_ QYIGE 96_ GAKTG 101_ IKECQ 106_ YQFRH 111_ RRWNC 116_ STVDN 121_ TSVFG 126_ RVMQI 131_ GSRET 136_ AFTYA 141_ VSAAG 146_ VVNAM 151_ SRACR 156_ EGELS 161_ TCGCS 166_ RAARP 171_ KDLPR 176_ DWLWG 181_ GCGDN 186_ IDYGY 191_ RFAKE 196_ FVDAR 201_ ERERI 206_ HAKGS 211_ YESAR 216_ ILMNL 221_ HNNEA 226_ GRRTV 231_ YNLAD 236_ VACKC 241_ HGVSG 246_ SCSLK 251_ TCWLQ 256_ LADFR 261_ KVGDA 266_ LKEKY 271_ DSAAA 276_ MRLNS 281_ RGKLV 286_ QVNSR 291_ FNSPT 296_ TQDLV 301_ YIDPS 306_ PDYCV 311_ RNEST 316_ GSLGT 321_ QGRLC 326_ NKTSE 331_ GMDGC 336_ ELMCC 341_ GRGYD 346_ QFKTV 351_ QTERC 356_ HCKFH 361_ WCCYV 366_ KCKKC 371_TEIVD
1: Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (By similarity). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor (PubMed:15735754). Mediates motility of melanoma cells (PubMed:17426020). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes (By similarity)