Prostaglandin-H2 D-isomerase (EC 5.3.99.2) (Beta-trace protein) (Cerebrin-28) (Glutathione-independent PGD synthase) (Lipocalin-type prostaglandin-D synthase) (L-PGDS) (Prostaglandin-D2 synthase) (PGD2 synthase) (PGDS) (PGDS2)
1_MATHH 6_ TLWMG 11_ LALLG 16_ VLGDL 21_ QAAPE 26_ AQVSV 31_ QPNFQ 36_ QDKFL 41_ GRWFS 46_ AGLAS 51_ NSSWL 56_ REKKA 61_ ALSMC 66_ KSVVA 71_ PATDG 76_ GLNLT 81_ STFLR 86_ KNQCE 91_ TRTML 96_ LQPAG 101_ SLGSY 106_ SYRSP 111_ HWGST 116_ YSVSV 121_ VETDY 126_ DQYAL 131_ LYSQG 136_ SKGPG 141_ EDFRM 146_ ATLYS 151_ RTQTP 156_ RAELK 161_ EKFTA 166_ FCKAQ 171_ GFTED 176_ TIVFL 181_PQTDK
1: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation (PubMed:20667974). Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (PubMed:20667974, PubMed:9475419). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity)