Transcription factor SOX-3
1_MRPVR 6_ ENSSG 11_ ARSPR 16_ VPADL 21_ ARSIL 26_ ISLPF 31_ PPDSL 36_ AHRPP 41_ SSAPT 46_ ESQGL 51_ FTVAA 56_ PAPGA 61_ PSPPA 66_ TLAHL 71_ LPAPA 76_ MYSLL 81_ ETELK 86_ NPVGT 91_ PTQAA 96_ GTGGP 101_ AAPGG 106_ AGKSS 111_ ANAAG 116_ GANSG 121_ GGSSG 126_ GASGG 131_ GGGTD 136_ QDRVK 141_ RPMNA 146_ FMVWS 151_ RGQRR 156_ KMALE 161_ NPKMH 166_ NSEIS 171_ KRLGA 176_ DWKLL 181_ TDAEK 186_ RPFID 191_ EAKRL 196_ RAVHM 201_ KEYPD 206_ YKYRP 211_ RRKTK 216_ TLLKK 221_ DKYSL 226_ PSGLL 231_ PPGAA 236_ AAAAA 241_ AAAAA 246_ AAASS 251_ PVGVG 256_ QRLDT 261_ YTHVN 266_ GWANG 271_ AYSLV 276_ QEQLG 281_ YAQPP 286_ SMSSP 291_ PPPPA 296_ LPPMH 301_ RYDMA 306_ GLQYS 311_ PMMPP 316_ GAQSY 321_ MNVAA 326_ AAAAA 331_ SGYGG 336_ MAPSA 341_ TAAAA 346_ AAYGQ 351_ QPATA 356_ AAAAA 361_ AAAAM 366_ SLGPM 371_ GSVVK 376_ SEPSS 381_ PPPAI 386_ ASHSQ 391_ RACLG 396_ DLRDM 401_ ISMYL 406_ PPGGD 411_ AADAA 416_ SPLPG 421_ GRLHG 426_ VHQHY 431_ QGAGT 436_ AVNGT 441_VPLTH
1: Transcription factor required during the formation of the hypothalamo-pituitary axis. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. Required also within the pharyngeal epithelia for craniofacial morphogenesis. Controls a genetic switch in male development. Is necessary for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (By similarity)