Ubiquitin-like modifier-activating enzyme 7 (Ubiquitin-activating enzyme 7) (D8) (Ubiquitin-activating enzyme E1 homolog)
1_MDALD 6_ ASKLL 11_ DEELY 16_ SRQLY 21_ VLGSP 26_ AMQRI 31_ QGARV 36_ LVSGL 41_ QGLGA 46_ EVAKN 51_ LVLMG 56_ VGSLT 61_ LHDPH 66_ PTCWS 71_ DLAAQ 76_ FLLSE 81_ QDLER 86_ SRAEA 91_ SQELL 96_ AQLNR 101_ AVQVV 106_ VHTGD 111_ ITEDL 116_ LLDFQ 121_ VVVLT 126_ AAKLE 131_ EQLKV 136_ GTLCH 141_ KHGVC 146_ FLAAD 151_ TRGLV 156_ GQLFC 161_ DFGED 166_ FTVQD 171_ PTEAE 176_ PLTAA 181_ IQHIS 186_ QGSPG 191_ ILTLR 196_ KGANT 201_ HYFRD 206_ GDLVT 211_ FSGIE 216_ GMVEL 221_ NDCDP 226_ RSIHV 231_ REDGS 236_ LEIGD 241_ TTTFS 246_ RYLRG 251_ GAITE 256_ VKRPK 261_ TVRHK 266_ SLDTA 271_ LLQPH 276_ VVAQS 281_ SQEVH 286_ HAHCL 291_ HQAFC 296_ ALHKF 301_ QHLHG 306_ RPPQP 311_ WDPVD 316_ AETVV 321_ GLARD 326_ LEPLK 331_ RTEEE 336_ PLEEP 341_ LDEAL 346_ VRTVA 351_ LSSAG 356_ VLSPM 361_ VAMLG 366_ AVAAQ 371_ EVLKA 376_ ISRKF 381_ MPLDQ 386_ WLYFD 391_ ALDCL 396_ PEDGE 401_ LLPSP 406_ EDCAL 411_ RGSRY 416_ DGQIA 421_ VFGAG 426_ FQEKL 431_ RRQHY 436_ LLVGA 441_ GAIGC 446_ ELLKV 451_ FALVG 456_ LGAGN 461_ SGGLT 466_ VVDMD 471_ HIERS 476_ NLSRQ 481_ FLFRS 486_ QDVGR 491_ PKAEV 496_ AAAAA 501_ RGLNP 506_ DLQVI 511_ PLTYP 516_ LDPTT 521_ EHIYG 526_ DNFFS 531_ RVDGV 536_ AAALD 541_ SFQAR 546_ RYVAA 551_ RCTHY 556_ LKPLL 561_ EAGTS 566_ GTWGS 571_ ATVFM 576_ PHVTE 581_ AYRAP 586_ ASAAA 591_ SEDAP 596_ YPVCT 601_ VRYFP 606_ STAEH 611_ TLQWA 616_ RHEFE 621_ ELFRL 626_ SAETI 631_ NHHQQ 636_ AHTSL 641_ ADMDE 646_ PQTLT 651_ LLKPV 656_ LGVLR 661_ VRPQN 666_ WQDCV 671_ AWALG 676_ HWKLC 681_ FHYGI 686_ KQLLR 691_ HFPPN 696_ KVLED 701_ GTPFW 706_ SGPKQ 711_ CPQPL 716_ EFDTN 721_ QDTHL 726_ LYVLA 731_ AANLY 736_ AQMHG 741_ LPGSQ 746_ DWTAL 751_ RELLK 756_ LLPQP 761_ DPQQM 766_ APIFA 771_ SNLEL 776_ ASASA 781_ EFGPE 786_ QQKEL 791_ NKALE 796_ VWSVG 801_ PPLKP 806_ LMFEK 811_ DDDSN 816_ FHVDF 821_ VVAAA 826_ SLRCQ 831_ NYGIP 836_ PVNRA 841_ QSKRI 846_ VGQII 851_ PAIAT 856_ TTAAV 861_ AGLLG 866_ LELYK 871_ VVSGP 876_ RPRSA 881_ FRHSY 886_ LHLAE 891_ NYLIR 896_ YMPFA 901_ PAIQT 906_ FHHLK 911_ WTSWD 916_ RLKVP 921_ AGQPE 926_ RTLES 931_ LLAHL 936_ QEQHG 941_ LRVRI 946_ LLHGS 951_ ALLYA 956_ AGWSP 961_ EKQAQ 966_ HLPLR 971_ VTELV 976_ QQLTG 981_ QAPAP 986_ GQRVL 991_ VLELS 996_ CEGDD 1001_ EDTAF 1006_PPLHY
1: E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation (PubMed:27545325). Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus (PubMed:16254333, PubMed:19073728, PubMed:29056542, PubMed:29743376, PubMed:37722521). For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition (PubMed:20133869). ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling (PubMed:27564865)