Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C)
1_MEPGS 6_ DDFLP 11_ PPECP 16_ VFEPS 21_ WAEFR 26_ DPLGY 31_ IAKIR 36_ PIAEK 41_ SGICK 46_ IRPPA 51_ DWQPP 56_ FAVEV 61_ DNFRF 66_ TPRIQ 71_ RLNEL 76_ EAQTR 81_ VKLNY 86_ LDQIA 91_ KFWEI 96_ QGSSL 101_ KIPNV 106_ ERRIL 111_ DLYSL 116_ SKIVV 121_ EEGGY 126_ EAICK 131_ DRRWA 136_ RVAQR 141_ LNYPP 146_ GKNIG 151_ SLLRS 156_ HYERI 161_ VYPYE 166_ MYQSG 171_ ANLVQ 176_ CNTRP 181_ FDNEE 186_ KDKEY 191_ KPHSI 196_ PLRQS 201_ VQPSK 206_ FNSYG 211_ RRAKR 216_ LQPDP 221_ EPTEE 226_ DIEKN 231_ PELKK 236_ LQIYG 241_ AGPKM 246_ MGLGL 251_ MAKDK 256_ TLRKK 261_ DKEGP 266_ ECPPT 271_ VVVKE 276_ ELGGD 281_ VKVES 286_ TSPKT 291_ FLESK 296_ EELSH 301_ SPEPC 306_ TKMTM 311_ RLRRN 316_ HSNAQ 321_ FIESY 326_ VCRMC 331_ SRGDE 336_ DDKLL 341_ LCDGC 346_ DDNYH 351_ IFCLL 356_ PPLPE 361_ IPKGV 366_ WRCPK 371_ CVMAE 376_ CKRPP 381_ EAFGF 386_ EQATR 391_ EYTLQ 396_ SFGEM 401_ ADSFK 406_ ADYFN 411_ MPVHM 416_ VPTEL 421_ VEKEF 426_ WRLVN 431_ SIEED 436_ VTVEY 441_ GADIH 446_ SKEFG 451_ SGFPV 456_ SDSKR 461_ HLTPE 466_ EEEYA 471_ TSGWN 476_ LNVMP 481_ VLEQS 486_ VLCHI 491_ NADIS 496_ GMKVP 501_ WLYVG 506_ MVFSA 511_ FCWHI 516_ EDHWS 521_ YSINY 526_ LHWGE 531_ PKTWY 536_ GVPSL 541_ AAEHL 546_ EEVMK 551_ KLTPE 556_ LFDSQ 561_ PDLLH 566_ QLVTL 571_ MNPNT 576_ LMSHG 581_ VPVVR 586_ TNQCA 591_ GEFVI 596_ TFPRA 601_ YHSGF 606_ NQGYN 611_ FAEAV 616_ NFCTA 621_ DWLPA 626_ GRQCI 631_ EHYRR 636_ LRRYC 641_ VFSHE 646_ ELICK 651_ MAACP 656_ EKLDL 661_ NLAAA 666_ VHKEM 671_ FIMVQ 676_ EERRL 681_ RKALL 686_ EKGIT 691_ EAERE 696_ AFELL 701_ PDDER 706_ QCIKC 711_ KTTCF 716_ LSALA 721_ CYDCP 726_ DGLVC 731_ LSHIN 736_ DLCKC 741_ SSSRQ 746_ YLRYR 751_ YTLDE 756_ LPAML 761_ HKLKV 766_ RAESF 771_ DTWAN 776_ KVRVA 781_ LEVED 786_ GRKRS 791_ LEELR 796_ ALESE 801_ ARERR 806_ FPNSE 811_ LLQQL 816_ KNCLS 821_ EAEAC 826_ VSRAL 831_ GLVSG 836_ QEAGP 841_ HRVAG 846_ LQMTL 851_ TELRA 856_ FLDQM 861_ NNLPC 866_ AMHQI 871_ GDVKG 876_ VLEQV 881_ EAYQA 886_ EAREA 891_ LASLP 896_ SSPGL 901_ LQSLL 906_ ERGRQ 911_ LGVEV 916_ PEAQQ 921_ LQRQV 926_ EQARW 931_ LDEVK 936_ RTLAP 941_ SARRG 946_ TLAVM 951_ RGLLV 956_ AGASV 961_ APSPA 966_ VDKAQ 971_ AELQE 976_ LLTIA 981_ ERWEE 986_ KAHLC 991_ LEARQ 996_ KHPPA 1001_ TLEAI 1006_ IREAE 1011_ NIPVH 1016_ LPNIQ 1021_ ALKEA 1026_ LAKAR 1031_ AWIAD 1036_ VDEIQ 1041_ NGDHY 1046_ PCLDD 1051_ LEGLV 1056_ AVGRD 1061_ LPVGL 1066_ EELRQ 1071_ LELQV 1076_ LTAHS 1081_ WREKA 1086_ SKTFL 1091_ KKNSC 1096_ YTLLE 1101_ VLCPC 1106_ ADAGS 1111_ DSTKR 1116_ SRWME 1121_ KELGL 1126_ YKSDT 1131_ ELLGL 1136_ SAQDL 1141_ RDPGS 1146_ VIVAF 1151_ KEGEQ 1156_ KEKEG 1161_ ILQLR 1166_ RTNSA 1171_ KPSPL 1176_ ASSST 1181_ ASSTT 1186_ SICVC 1191_ GQVLA 1196_ GAGAL 1201_ QCDLC 1206_ QDWFH 1211_ GRCVS 1216_ VPRLL 1221_ SSPRP 1226_ NPTSS 1231_ PLLAW 1236_ WEWDT 1241_ KFLCP 1246_ LCMRS 1251_ RRPRL 1256_ ETILA 1261_ LLVAL 1266_ QRLPV 1271_ RLPEG 1276_ EALQC 1281_ LTERA 1286_ ISWQG 1291_ RARQA 1296_ LASED 1301_ VTALL 1306_ GRLAE 1311_ LRQRL 1316_ QAEPR 1321_ PEEPP 1326_ NYPAA 1331_ PASDP 1336_ LREGS 1341_ GKDMP 1346_ KVQGL 1351_ LENGD 1356_ SVTSP 1361_ EKVAP 1366_ EEGSG 1371_ KRDLE 1376_ LLSSL 1381_ LPQLT 1386_ GPVLE 1391_ LPEAT 1396_ RAPLE 1401_ ELMME 1406_ GDLLE 1411_ VTLDE 1416_ NHSIW 1421_ QLLQA 1426_ GQPPD 1431_ LERIR 1436_ TLLEL 1441_ EKAER 1446_ HGSRA 1451_ RGRAL 1456_ ERRRR 1461_ RKVDR 1466_ GGEGD 1471_ DPARE 1476_ ELEPK 1481_ RVRSS 1486_ GPEAE 1491_ EVQEE 1496_ EELEE 1501_ ETGGE 1506_ GPPAP 1511_ IPTTG 1516_ SPSTQ 1521_ ENQNG 1526_ LEPAE 1531_ GTTSG 1536_ PSAPF 1541_ STLTP 1546_ RLHLP 1551_CPQQP
1: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity)