Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
1_MRLSK 6_ TLVDM 11_ DMADY 16_ SAALD 21_ PAYTT 26_ LEFEN 31_ VQVLT 36_ MGNDT 41_ SPSEG 46_ TNLNA 51_ PNSLG 56_ VSALC 61_ AICGD 66_ RATGK 71_ HYGAS 76_ SCDGC 81_ KGFFR 86_ RSVRK 91_ NHMYS 96_ CRFSR 101_ QCVVD 106_ KDKRN 111_ QCRYC 116_ RLKKC 121_ FRAGM 126_ KKEAV 131_ QNERD 136_ RISTR 141_ RSSYE 146_ DSSLP 151_ SINAL 156_ LQAEV 161_ LSRQI 166_ TSPVS 171_ GINGD 176_ IRAKK 181_ IASIA 186_ DVCES 191_ MKEQL 196_ LVLVE 201_ WAKYI 206_ PAFCE 211_ LPLDD 216_ QVALL 221_ RAHAG 226_ EHLLL 231_ GATKR 236_ SMVFK 241_ DVLLL 246_ GNDYI 251_ VPRHC 256_ PELAE 261_ MSRVS 266_ IRILD 271_ ELVLP 276_ FQELQ 281_ IDDNE 286_ YAYLK 291_ AIIFF 296_ DPDAK 301_ GLSDP 306_ GKIKR 311_ LRSQV 316_ QVSLE 321_ DYIND 326_ RQYDS 331_ RGRFG 336_ ELLLL 341_ LPTLQ 346_ SITWQ 351_ MIEQI 356_ QFIKL 361_ FGMAK 366_ IDNLL 371_ QEMLL 376_ GGSPS 381_ DAPHA 386_ HHPLH 391_ PHLMQ 396_ EHMGT 401_ NVIVA 406_ NTMPT 411_ HLSNG 416_ QMCEW 421_ PRPRG 426_ QAATP 431_ ETPQP 436_ SPPGG 441_ SGSEP 446_ YKLLP 451_ GAVAT 456_ IVKPL 461_ SAIPQ 466_PTITK
1: Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698)