Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
1_MSAIQ 6_ AAWPS 11_ GTECI 16_ AKYNF 21_ HGTAE 26_ QDLPF 31_ CKGDV 36_ LTIVA 41_ VTKDP 46_ NWYKA 51_ KNKVG 56_ REGII 61_ PANYV 66_ QKREG 71_ VKAGT 76_ KLSLM 81_ PWFHG 86_ KITRE 91_ QAERL 96_ LYPPE 101_ TGLFL 106_ VREST 111_ NYPGD 116_ YTLCV 121_ SCDGK 126_ VEHYR 131_ IMYHA 136_ SKLSI 141_ DEEVY 146_ FENLM 151_ QLVEH 156_ YTSDA 161_ DGLCT 166_ RLIKP 171_ KVMEG 176_ TVAAQ 181_ DEFYR 186_ SGWAL 191_ NMKEL 196_ KLLQT 201_ IGKGE 206_ FGDVM 211_ LGDYR 216_ GNKVA 221_ VKCIK 226_ NDATA 231_ QAFLA 236_ EASVM 241_ TQLRH 246_ SNLVQ 251_ LLGVI 256_ VEEKG 261_ GLYIV 266_ TEYMA 271_ KGSLV 276_ DYLRS 281_ RGRSV 286_ LGGDC 291_ LLKFS 296_ LDVCE 301_ AMEYL 306_ EGNNF 311_ VHRDL 316_ AARNV 321_ LVSED 326_ NVAKV 331_ SDFGL 336_ TKEAS 341_ STQDT 346_ GKLPV 351_ KWTAP 356_ EALRE 361_ KKFST 366_ KSDVW 371_ SFGIL 376_ LWEIY 381_ SFGRV 386_ PYPRI 391_ PLKDV 396_ VPRVE 401_ KGYKM 406_ DAPDG 411_ CPPAV 416_ YEVMK 421_ NCWHL 426_ DAAMR 431_ PSFLQ 436_ LREQL 441_EHIKT
1: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK