Glycine--tRNA ligase (EC 6.1.1.14) (Diadenosine tetraphosphate synthetase) (Ap4A synthetase) (EC 2.7.7.-) (Glycyl-tRNA synthetase) (GlyRS) (Glycyl-tRNA synthetase 1)
1_MPSPR 6_ PVLLR 11_ GARAA 16_ LLLLL 21_ PPRLL 26_ ARPSL 31_ LLRRS 36_ LSAAS 41_ CPPIS 46_ LPAAA 51_ SRSSM 56_ DGAGA 61_ EEVLA 66_ PLRLA 71_ VRQQG 76_ DLVRK 81_ LKEDK 86_ APQVD 91_ VDKAV 96_ AELKA 101_ RKRVL 106_ EAKEL 111_ ALQPK 116_ DDIVD 121_ RAKME 126_ DTLKR 131_ RFFYD 136_ QAFAI 141_ YGGVS 146_ GLYDF 151_ GPVGC 156_ ALKNN 161_ IIQTW 166_ RQHFI 171_ QEEQI 176_ LEIDC 181_ TMLTP 186_ EPVLK 191_ TSGHV 196_ DKFAD 201_ FMVKD 206_ VKNGE 211_ CFRAD 216_ HLLKA 221_ HLQKL 226_ MSDKK 231_ CSVEK 236_ KSEME 241_ SVLAQ 246_ LDNYG 251_ QQELA 256_ DLFVN 261_ YNVKS 266_ PITGN 271_ DLSPP 276_ VSFNL 281_ MFKTF 286_ IGPGG 291_ NMPGY 296_ LRPET 301_ AQGIF 306_ LNFKR 311_ LLEFN 316_ QGKLP 321_ FAAAQ 326_ IGNSF 331_ RNEIS 336_ PRSGL 341_ IRVRE 346_ FTMAE 351_ IEHFV 356_ DPSEK 361_ DHPKF 366_ QNVAD 371_ LHLYL 376_ YSAKA 381_ QVSGQ 386_ SARKM 391_ RLGDA 396_ VEQGV 401_ INNTV 406_ LGYFI 411_ GRIYL 416_ YLTKV 421_ GISPD 426_ KLRFR 431_ QHMEN 436_ EMAHY 441_ ACDCW 446_ DAESK 451_ TSYGW 456_ IEIVG 461_ CADRS 466_ CYDLS 471_ CHARA 476_ TKVPL 481_ VAEKP 486_ LKEPK 491_ TVNVV 496_ QFEPS 501_ KGAIG 506_ KAYKK 511_ DAKLV 516_ MEYLA 521_ ICDEC 526_ YITEM 531_ EMLLN 536_ EKGEF 541_ TIETE 546_ GKTFQ 551_ LTKDM 556_ INVKR 561_ FQKTL 566_ YVEEV 571_ VPNVI 576_ EPSFG 581_ LGRIM 586_ YTVFE 591_ HTFHV 596_ REGDE 601_ QRTFF 606_ SFPAV 611_ VAPFK 616_ CSVLP 621_ LSQNQ 626_ EFMPF 631_ VKELS 636_ EALTR 641_ HGVSH 646_ KVDDS 651_ SGSIG 656_ RRYAR 661_ TDEIG 666_ VAFGV 671_ TIDFD 676_ TVNKT 681_ PHTAT 686_ LRDRD 691_ SMRQI 696_ RAEIS 701_ ELPSI 706_ VQDLA 711_ NGNIT 716_ WADVE 721_ ARYPL 726_ FEGQE 731_TGKKE
1: Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017)