Reduced folate transporter (FOLT) (Intestinal folate carrier 1) (IFC-1) (Placental folate transporter) (Reduced folate carrier protein) (RFC) (hRFC) (Reduced folate transporter 1) (RFT-1) (Solute carrier family 19 member 1) (hSLC19A1)
1_MVPSS 6_ PAVEK 11_ QVPVE 16_ PGPDP 21_ ELRSW 26_ RHLVC 31_ YLCFY 36_ GFMAQ 41_ IRPGE 46_ SFITP 51_ YLLGP 56_ DKNFT 61_ REQVT 66_ NEITP 71_ VLSYS 76_ YLAVL 81_ VPVFL 86_ LTDYL 91_ RYTPV 96_ LLLQG 101_ LSFVS 106_ VWLLL 111_ LLGHS 116_ VAHMQ 121_ LMELF 126_ YSVTM 131_ AARIA 136_ YSSYI 141_ FSLVR 146_ PARYQ 151_ RVAGY 156_ SRAAV 161_ LLGVF 166_ TSSVL 171_ GQLLV 176_ TVGRV 181_ SFSTL 186_ NYISL 191_ AFLTF 196_ SVVLA 201_ LFLKR 206_ PKRSL 211_ FFNRD 216_ DRGRC 221_ ETSAS 226_ ELERM 231_ NPGPG 236_ GKLGH 241_ ALRVA 246_ CGDSV 251_ LARML 256_ RELGD 261_ SLRRP 266_ QLRLW 271_ SLWWV 276_ FNSAG 281_ YYLVV 286_ YYVHI 291_ LWNEV 296_ DPTTN 301_ SARVY 306_ NGAAD 311_ AASTL 316_ LGAIT 321_ SFAAG 326_ FVKIR 331_ WARWS 336_ KLLIA 341_ GVTAT 346_ QAGLV 351_ FLLAH 356_ TRHPS 361_ SIWLC 366_ YAAFV 371_ LFRGS 376_ YQFLV 381_ PIATF 386_ QIASS 391_ LSKEL 396_ CALVF 401_ GVNTF 406_ FATIV 411_ KTIIT 416_ FIVSD 421_ VRGLG 426_ LPVRK 431_ QFQLY 436_ SVYFL 441_ ILSII 446_ YFLGA 451_ MLDGL 456_ RHCQR 461_ GHHPR 466_ QPPAQ 471_ GLRSA 476_ AEEKA 481_ AQALS 486_ VQDKG 491_ LGGLQ 496_ PAQSP 501_ PLSPE 506_ DSLGA 511_ VGPAS 516_ LEQRQ 521_ SDPYL 526_ AQAPA 531_ PQAAE 536_ FLSPV 541_ TTPSP 546_ CTLCS 551_ AQASG 556_ PEAAD 561_ ETCPQ 566_ LAVHP 571_ PGVSK 576_ LGLQC 581_ LPSDG 586_VQNVN
1: Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions (PubMed:10787414, PubMed:15337749, PubMed:16115875, PubMed:22554803, PubMed:31126740, PubMed:31511694, PubMed:32276275, PubMed:36071163, PubMed:36265513, PubMed:36575193, PubMed:7826387, PubMed:9041240). Acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses (PubMed:31126740, PubMed:31511694, PubMed:36745868). Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (PubMed:22554803, PubMed:31126740, PubMed:31511694). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:10787414, PubMed:14609557, PubMed:22554803, PubMed:36071163, PubMed:36265513, PubMed:36575193). Also mediates the import of antifolate drug methotrexate (PubMed:22554803, PubMed:36071163, PubMed:7615551, PubMed:7641195, PubMed:9767079). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (PubMed:22554803)