Pituitary adenylate cyclase-activating polypeptide type I receptor (PACAP type I receptor) (PACAP-R-1) (PACAP-R1)
1_MAGVV 6_ HVSLA 11_ ALLLL 16_ PMAPA 21_ MHSDC 26_ IFKKE 31_ QAMCL 36_ EKIQR 41_ ANELM 46_ GFNDS 51_ SPGCP 56_ GMWDN 61_ ITCWK 66_ PAHVG 71_ EMVLV 76_ SCPEL 81_ FRIFN 86_ PDQVW 91_ ETETI 96_ GESDF 101_ GDSNS 106_ LDLSD 111_ MGVVS 116_ RNCTE 121_ DGWSE 126_ PFPHY 131_ FDACG 136_ FDEYE 141_ SETGD 146_ QDYYY 151_ LSVKA 156_ LYTVG 161_ YSTSL 166_ VTLTT 171_ AMVIL 176_ CRFRK 181_ LHCTR 186_ NFIHM 191_ NLFVS 196_ FMLRA 201_ ISVFI 206_ KDWIL 211_ YAEQD 216_ SNHCF 221_ ISTVE 226_ CKAVM 231_ VFFHY 236_ CVVSN 241_ YFWLF 246_ IEGLY 251_ LFTLL 256_ VETFF 261_ PERRY 266_ FYWYT 271_ IIGWG 276_ TPTVC 281_ VTVWA 286_ TLRLY 291_ FDDTG 296_ CWDMN 301_ DSTAL 306_ WWVIK 311_ GPVVG 316_ SIMVN 321_ FVLFI 326_ GIIVI 331_ LVQKL 336_ QSPDM 341_ GGNES 346_ SIYLR 351_ LARST 356_ LLLIP 361_ LFGIH 366_ YTVFA 371_ FSPEN 376_ VSKRE 381_ RLVFE 386_ LGLGS 391_ FQGFV 396_ VAVLY 401_ CFLNG 406_ EVQAE 411_ IKRKW 416_ RSWKV 421_ NRYFA 426_ VDFKH 431_ RHPSL 436_ ASSGV 441_ NGGTQ 446_ LSILS 451_ KSSSQ 456_ IRMSG 461_LPADN
1: G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:32047270, PubMed:33715378, PubMed:35477937, PubMed:36385145). Binds both PACAP27 and PACAP38 bioactive peptides (PubMed:32047270, PubMed:35477937, PubMed:36385145). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:32047270, PubMed:33715378, PubMed:35477937, PubMed:36385145). May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (PubMed:32047270, PubMed:33715378)