Vasoactive intestinal polypeptide receptor 2 (VIP-R-2) (Helodermin-preferring VIP receptor) (Pituitary adenylate cyclase-activating polypeptide type III receptor) (PACAP type III receptor) (PACAP-R-3) (PACAP-R3) (VPAC2)
1_MRTLL 6_ PPALL 11_ TCWLL 16_ APVNS 21_ IHPEC 26_ RFHLE 31_ IQEEE 36_ TKCAE 41_ LLRSQ 46_ TEKHK 51_ ACSGV 56_ WDNIT 61_ CWRPA 66_ NVGET 71_ VTVPC 76_ PKVFS 81_ NFYSK 86_ AGNIS 91_ KNCTS 96_ DGWSE 101_ TFPDF 106_ VDACG 111_ YSDPE 116_ DESKI 121_ TFYIL 126_ VKAIY 131_ TLGYS 136_ VSLMS 141_ LATGS 146_ IILCL 151_ FRKLH 156_ CTRNY 161_ IHLNL 166_ FLSFI 171_ LRAIS 176_ VLVKD 181_ DVLYS 186_ SSGTL 191_ HCPDQ 196_ PSSWV 201_ GCKLS 206_ LVFLQ 211_ YCIMA 216_ NFFWL 221_ LVEGL 226_ YLHTL 231_ LVAML 236_ PPRRC 241_ FLAYL 246_ LIGWG 251_ LPTVC 256_ IGAWT 261_ AARLY 266_ LEDTG 271_ CWDTN 276_ DHSVP 281_ WWVIR 286_ IPILI 291_ SIIVN 296_ FVLFI 301_ SIIRI 306_ LLQKL 311_ TSPDV 316_ GGNDQ 321_ SQYKR 326_ LAKST 331_ LLLIP 336_ LFGVH 341_ YMVFA 346_ VFPIS 351_ ISSKY 356_ QILFE 361_ LCLGS 366_ FQGLV 371_ VAVLY 376_ CFLNS 381_ EVQCE 386_ LKRKW 391_ RSRCP 396_ TPSAS 401_ RDYRV 406_ CGSSF 411_ SRNGS 416_ EGALQ 421_ FHRGS 426_ RAQSF 431_LQTET
1: G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:7811244, PubMed:35477937, PubMed:8933357). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of potency PACAP38 = VIP > PACAP27 (PubMed:35477937, PubMed:8933357). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:7811244, PubMed:35477937, PubMed:8933357). May be coupled to phospholipase C