5-hydroxytryptamine receptor 2B (5-HT-2B) (5-HT2B) (Serotonin receptor 2B)
1_MALSY 6_ RVSEL 11_ QSTIP 16_ EHILQ 21_ STFVH 26_ VISSN 31_ WSGLQ 36_ TESIP 41_ EEMKQ 46_ IVEEQ 51_ GNKLH 56_ WAALL 61_ ILMVI 66_ IPTIG 71_ GNTLV 76_ ILAVS 81_ LEKKL 86_ QYATN 91_ YFLMS 96_ LAVAD 101_ LLVGL 106_ FVMPI 111_ ALLTI 116_ MFEAM 121_ WPLPL 126_ VLCPA 131_ WLFLD 136_ VLFST 141_ ASIMH 146_ LCAIS 151_ VDRYI 156_ AIKKP 161_ IQANQ 166_ YNSRA 171_ TAFIK 176_ ITVVW 181_ LISIG 186_ IAIPV 191_ PIKGI 196_ ETDVD 201_ NPNNI 206_ TCVLT 211_ KERFG 216_ DFMLF 221_ GSLAA 226_ FFTPL 231_ AIMIV 236_ TYFLT 241_ IHALQ 246_ KKAYL 251_ VKNKP 256_ PQRLT 261_ WLTVS 266_ TVFQR 271_ DETPC 276_ SSPEK 281_ VAMLD 286_ GSRKD 291_ KALPN 296_ SGDET 301_ LMRRT 306_ STIGK 311_ KSVQT 316_ ISNEQ 321_ RASKV 326_ LGIVF 331_ FLFLL 336_ MWCPF 341_ FITNI 346_ TLVLC 351_ DSCNQ 356_ TTLQM 361_ LLEIF 366_ VWIGY 371_ VSSGV 376_ NPLVY 381_ TLFNK 386_ TFRDA 391_ FGRYI 396_ TCNYR 401_ ATKSV 406_ KTLRK 411_ RSSKI 416_ YFRNP 421_ MAENS 426_ KFFKK 431_ HGIRN 436_ GINPA 441_ MYQSP 446_ MRLRS 451_ STIQS 456_ SSIIL 461_ LDTLL 466_ LTENE 471_ GDKTE 476_EQVSY
1: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:18703043, PubMed:23519210, PubMed:7926008, PubMed:8078486, PubMed:8143856, PubMed:8882600). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538, PubMed:30127358, PubMed:36087581, PubMed:7926008, PubMed:8078486, PubMed:8143856). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:23519215, PubMed:28129538, PubMed:8078486, PubMed:8143856, PubMed:8882600). HTR2B is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (PubMed:18703043, PubMed:23519215, PubMed:28129538, PubMed:30127358, PubMed:36087581, PubMed:8078486, PubMed:8143856, PubMed:8882600). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538, PubMed:30127358, PubMed:36087581). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain (By similarity). Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development (By similarity). Protects cardiomyocytes against apoptosis (By similarity). Plays a role in the adaptation of pulmonary arteries to chronic hypoxia (By similarity). Plays a role in vasoconstriction (By similarity). Required for normal osteoblast function and proliferation, and for maintaining normal bone density (By similarity). Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity)