C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD antigen CD192)
1_MLSTS 6_ RSRFI 11_ RNTNE 16_ SGEEV 21_ TTFFD 26_ YDYGA 31_ PCHKF 36_ DVKQI 41_ GAQLL 46_ PPLYS 51_ LVFIF 56_ GFVGN 61_ MLVVL 66_ ILINC 71_ KKLKC 76_ LTDIY 81_ LLNLA 86_ ISDLL 91_ FLITL 96_ PLWAH 101_ SAANE 106_ WVFGN 111_ AMCKL 116_ FTGLY 121_ HIGYF 126_ GGIFF 131_ IILLT 136_ IDRYL 141_ AIVHA 146_ VFALK 151_ ARTVT 156_ FGVVT 161_ SVITW 166_ LVAVF 171_ ASVPG 176_ IIFTK 181_ CQKED 186_ SVYVC 191_ GPYFP 196_ RGWNN 201_ FHTIM 206_ RNILG 211_ LVLPL 216_ LIMVI 221_ CYSGI 226_ LKTLL 231_ RCRNE 236_ KKRHR 241_ AVRVI 246_ FTIMI 251_ VYFLF 256_ WTPYN 261_ IVILL 266_ NTFQE 271_ FFGLS 276_ NCEST 281_ SQLDQ 286_ ATQVT 291_ ETLGM 296_ THCCI 301_ NPIIY 306_ AFVGE 311_ KFRSL 316_ FHIAL 321_ GCRIA 326_ PLQKP 331_ VCGGP 336_ GVRPG 341_ KNVKV 346_ TTQGL 351_ LDGRG 356_ KGKSI 361_ GRAPE 366_ASLQD
1: Key functional receptor for CCL2 but can also bind CCL7, and CCL12 (PubMed:23408426, PubMed:38157855, PubMed:8048929, PubMed:8146186). Also transduces signaling mediated by CCL13 (PubMed:38157855). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (PubMed:38157855). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity)
2: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection