T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (B70) (BU63) (CTLA-4 counter-receptor B7.2) (FUN-1) (CD antigen CD86)
1_MDPQC 6_ TMGLS 11_ NILFV 16_ MAFLL 21_ SGAAP 26_ LKIQA 31_ YFNET 36_ ADLPC 41_ QFANS 46_ QNQSL 51_ SELVV 56_ FWQDQ 61_ ENLVL 66_ NEVYL 71_ GKEKF 76_ DSVHS 81_ KYMGR 86_ TSFDS 91_ DSWTL 96_ RLHNL 101_ QIKDK 106_ GLYQC 111_ IIHHK 116_ KPTGM 121_ IRIHQ 126_ MNSEL 131_ SVLAN 136_ FSQPE 141_ IVPIS 146_ NITEN 151_ VYINL 156_ TCSSI 161_ HGYPE 166_ PKKMS 171_ VLLRT 176_ KNSTI 181_ EYDGV 186_ MQKSQ 191_ DNVTE 196_ LYDVS 201_ ISLSV 206_ SFPDV 211_ TSNMT 216_ IFCIL 221_ ETDKT 226_ RLLSS 231_ PFSIE 236_ LEDPQ 241_ PPPDH 246_ IPWIT 251_ AVLPT 256_ VIICV 261_ MVFCL 266_ ILWKW 271_ KKKKR 276_ PRNSY 281_ KCGTN 286_ TMERE 291_ ESEQT 296_ KKREK 301_ IHIPE 306_ RSDEA 311_ QRVFK 316_ SSKTS 321_SCDKS
1: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4 (PubMed:12196291). May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity)
2: Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation
3: (Microbial infection) Acts as a receptor for adenovirus subgroup B